Osteoarthritis is the most prevalent joint disease and a frequent cause of joint pain, functional loss, and
disability. Osteoarthritis often becomes chronic, and conventional treatments have demonstrated only modest clinical
benefits without lesion reversal. Cell-based therapies have shown encouraging results in both animal studies and a few
human case reports. We designed a pilot study to assess the feasibility and safety of osteoarthritis treatment with
mesenchymal stromal cells (MSCs) in humans and to obtain early efficacy information for this treatment.
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