Show simple item record

dc.contributor.authorTapias, Victor
dc.contributor.authorCannon, Jason R.
dc.contributor.authorGreenamyre, J. Timothy
dc.date.accessioned2024-01-01T21:39:15Z
dc.date.available2024-01-01T21:39:15Z
dc.date.issued2014
dc.identifier.citationNeurobiology of Aging, Mayo 2014, vol. 35, n. 5. p. 1162-1176es
dc.identifier.issn0197-4580es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/63881
dc.descriptionProducción Científicaes
dc.description.abstractNumerous factors contribute to the death of substantia nigra (SN) dopamine (DA) neurons in Parkinson's disease (PD). Compelling evidence implicates mitochondrial deficiency, oxidative stress, and inflammation as important pathogenic factors in PD. Chronic exposure of rats to rotenone causes a PD-like syndrome, in part by causing oxidative damage and inflammation in substantia nigra. Pomegranate juice (PJ) has the greatest composite antioxidant potency index among beverages, and it has been demonstrated to have protective effects in a transgenic model of Alzheimer's disease. The present study was designed to examine the potential neuroprotective effects of PJ in the rotenone model of PD. Oral administration of PJ did not mitigate or prevent experimental PD but instead increased nigrostriatal terminal depletion, DA neuron loss, the inflammatory response, and caspase activation, thereby heightening neurodegeneration. The mechanisms underlying this effect are uncertain, but the finding that PJ per se enhanced nitrotyrosine, inducible nitric oxide synthase, and activated caspase-3 expression in nigral DA neurons is consistent with its potential pro-oxidant activity.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titlePomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's diseasees
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016/j.neurobiolaging.2013.10.077es
dc.identifier.publicationfirstpage1162es
dc.identifier.publicationissue5es
dc.identifier.publicationlastpage1176es
dc.identifier.publicationtitleNeurobiology of Aginges
dc.identifier.publicationvolume35es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.type.hasVersioninfo:eu-repo/semantics/draftes


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record