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    •   UVaDOC Startseite
    • WISSENSCHAFTLICHE ARBEITEN
    • Departamentos
    • Dpto. Bioquímica y Biología Molecular y Fisiología
    • DEP06 - Artículos de revista
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    • DEP06 - Artículos de revista
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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/63890

    Título
    Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism
    Autor
    Allen, Erika N.
    Potdar, Sneha
    Tapias Molina, VictorAutoridad UVA Orcid
    Parmar, Mayur
    Mizuno, Cassia S.
    Rimando, Agnes
    Cavanaugh, Jane E.
    Año del Documento
    2018
    Descripción
    Producción Científica
    Documento Fuente
    The Journal of Nutritional Biochemistry, Abril 2018, vol. 54. p. 77-86
    Zusammenfassung
    Age-related declines in motor function may be due, in part, to an increase in oxidative stress in the aging brain leading to dopamine (DA) neuronal cell death. In this study, we examined the neuroprotective effects of natural antioxidants resveratrol and pinostilbene against age-related DAergic cell death and motor dysfunction using SH-SY5Y neuroblastoma cells and young, middle-aged, and old male C57BL/6 mice. Resveratrol and pinostilbene protected SH-SY5Y cells from a DA-induced decrease in cell viability. Dietary supplementation with resveratrol and pinostilbene inhibited the decline of motor function observed with age. While DA and its metabolites (DOPAC and HVA), dopamine transporter, and tyrosine hydroxylase levels remain unchanged during aging or treatment, resveratrol and pinostilbene increased ERK1/2 activation in vitro and in vivo in an age-dependent manner. Inhibition of ERK1/2 in SH-SY5Y cells decreased the protective effects of both compounds. These data suggest that resveratrol and pinostilbene alleviate age-related motor decline via the promotion of DA neuronal survival and activation of the ERK1/2 pathways.
    ISSN
    0955-2863
    Revisión por pares
    SI
    DOI
    10.1016/j.jnutbio.2017.10.015
    Patrocinador
    http://uvadoc.uva.es/handle/10324/63890
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/63890
    Tipo de versión
    info:eu-repo/semantics/draft
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [353]
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    Nombre:
    Allen et al 2018_J Nutr Biochem.pdf
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