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    • Dpto. Bioquímica y Biología Molecular y Fisiología
    • DEP06 - Artículos de revista
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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/64302

    Título
    Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor
    Autor
    Casas Requena, JavierAutoridad UVA Orcid
    Brzostek, Joanna
    Zarnitsyna, Veronika I.
    Hong, Jin-sung
    Wei, Qianru
    Hoerter, John A. H.
    Fu, Guo
    Ampudia, Jeanette
    Zamoyska, Rose
    Zhu, Cheng
    Gascoigne, Nicholas R. J.
    Año del Documento
    2014
    Descripción
    Producción Científica
    Documento Fuente
    Nature Communications 5:5624. https://doi.org/10.1038/ncomms6624
    Abstract
    The earliest molecular events in T-cell recognition have not yet been fully described, and the initial T-cell receptor (TCR)-triggering mechanism remains a subject of controversy. Here, using total internal reflection/Forster resonance energy transfer microscopy, we observe a two-stage interaction between TCR, CD8 and major histocompatibility complex (MHC)-peptide. There is an early (within seconds) interaction between CD3ζ and the coreceptor CD8 that is independent of the binding of CD8 to MHC, but that requires CD8 association with Lck. Later (several minutes) CD3ζ–CD8 interactions require CD8–MHC binding. Lck can be found free or bound to the coreceptor. This work indicates that the initial TCR-triggering event is induced by free Lck. The early signalling events that trigger initial T-cell receptor signalling are not clearly defined. Here the authors show that this occurs in two stages, the first between the CD8 coreceptor and CD3 requiring Lck association to CD8, while the second interaction requires binding of major histocompatibility molecules.
    Revisión por pares
    SI
    DOI
    10.1038/ncomms6624
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/64302
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [353]
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    Universidad de Valladolid

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