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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/64507

    Título
    Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures
    Autor
    Ramírez, Beatriz E.
    Sánchez García, Ana María de los ÁngelesAutoridad UVA Orcid
    Herreras Cantalapiedra, José MaríaAutoridad UVA Orcid
    Fernández Martínez, ItziarAutoridad UVA Orcid
    García-Sancho Martín, Francisco JavierAutoridad UVA Orcid
    Nieto Miguel, TeresaAutoridad UVA Orcid
    Calonge, MargaritaAutoridad UVA Orcid
    Año del Documento
    2015
    Editorial
    Hindawi Publishing Corporation
    Descripción
    Producción Científica
    Documento Fuente
    BioMed Research Intternational. 2015;2015:408495. p. 1-19
    Resumen
    Objective. To evaluate outcomes of cultivated limbal epithelial transplantation (CLET) for management of ocular surface failure due to limbal stem cell deficiency (LSCD). Design. Prospective, noncomparative, interventional case series and extensive comparison with recent similar studies. Participants. Twenty eyes with LSCD underwent CLET (11 autologous; 9 allogeneic) and were followed up for 3 years. Etiologies were divided into 3 prognostic categories: Group 1, chemical injuries (7 eyes); Group 2, immune-based inflammation (4 eyes); and Group 3, noninflammatory diseases (9 eyes). Intervention. Autologous and allogeneic limbal epithelial cells were cultivated on amniotic membranes and transplanted. Evaluations were based on clinical parameters, survival analysis, and in vivo confocal microscopy (IVCM). European Union Tissues/Cells Directive and good manufacturing procedures were followed. Main Outcome Measures. Improved clinical parameters, absence of epithelial defects, and improved central corneal epithelial phenotype. Results. Success rate was 80% at 1-2 years and 75% at 3 years. Autografts and allografts had similar survival. Success rate was significantly lower in prognostic Group 1 (42.9%) than in Groups 2-3 (100% each). All clinical parameters improved substantially. By IVCM, 80% of cases improved in epithelial status. Conclusions. CLET improved corneal epithelium quality, with subsequent improvement in symptoms, quality of life, and vision. These results confirm that CLET is a valid therapy for ocular surface failure.
    ISSN
    2314-6133
    Revisión por pares
    SI
    DOI
    10.1155/2015/408495
    Patrocinador
    This study received a financial support from the Advanced Therapies Program (SAS/2481/2009), Ministry of Health, Spain; Regional Center for Regenerative Medicine and Cell Therapy, SAN 1178/200, Castilla y León, Spain. Beatriz E. Ramírez held a predoctoral scholarship from The Carolina Foundation, Ministry of Foreign Affairs, Spain.
    Version del Editor
    https://www.hindawi.com/journals/bmri/2015/408495/
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/64507
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IOBA - Artículos de revista [83]
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    Nombre:
    2015 Ramirez et al Biomed Res Int_Stem Cell Therapy for Corneal Epithelium Regeneration following Good Manufacturing and Clinical Procedures.pdf
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    4.323Mb
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    Universidad de Valladolid

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