Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has become a major
public health problem, but the prevalence of fibrosis associated with non-alcoholic
steatohepatitis (NASH) is largely unknown in the general population. This study aimed
to provide an updated estimation of the prevalence of NASH fibrosis in Spain.
Methods: This was an observational, retrospective, cross-sectional, population-based
study with merged data from two Spanish datasets: a large (N = 12 246) populationbased cohort (ETHON), including transient elastography (TE) data, and a contemporary multi-centric biopsy-proven NASH cohort with paired TE data from tertiary
centres (N = 501). Prevalence for each NASH fibrosis stage was estimated by crossing
TE data from ETHON dataset with histology data from the biopsy-proven cohort.
