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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/65378

    Título
    Kv1.3 Channel Inhibition Limits Uremia-Induced Calcification in Mouse and Human Vascular Smooth Muscle
    Autor
    Cazaña Pérez, Violeta
    Cidad Velasco, María Del PilarAutoridad UVA Orcid
    Navarro-González, Juan F.
    Rojo Mencia, JorgeAutoridad UVA Orcid
    Jaisser, Frederic
    López López, José RamónAutoridad UVA Orcid
    Álvarez de la Rosa, Diego
    Giraldez, Teresa
    Pérez García, María TeresaAutoridad UVA Orcid
    Año del Documento
    2021
    Documento Fuente
    Function, Volume 2, Issue 1, 2021, zqaa036, https://doi.org/10.1093/function/zqaa036
    Resumen
    Chronic kidney disease (CKD) significantly increases cardiovascular risk. In advanced CKD stages, accumulation of toxic circulating metabolites and mineral metabolism alterations triggers vascular calcification, characterized by vascular smooth muscle cell (VSMC) transdifferentiation and loss of the contractile phenotype. Phenotypic modulation of VSMC occurs with significant changes in gene expression. Even though ion channels are an integral component of VSMC function, the effects of uremia on ion channel remodeling has not been explored. We used an in vitro model of uremia-induced calcification of human aorta smooth muscle cells (HASMCs) to study the expression of 92 ion channel subunit genes. Uremic serum-induced extensive remodeling of ion channel expression consistent with loss of excitability but different from the one previously associated with transition from contractile to proliferative phenotypes. Among the ion channels tested, we found increased abundance and activity of voltage-dependent K+ channel Kv1.3. Enhanced Kv1.3 expression was also detected in aorta from a mouse model of CKD. Pharmacological inhibition or genetic ablation of Kv1.3 decreased the amount of calcium phosphate deposition induced by uremia, supporting an important role for this channel on uremia-induced VSMC calcification.
    Revisión por pares
    SI
    DOI
    10.1093/function/zqaa036
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/65378
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • VASCUMIT - Artículos de revista [47]
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    Nombre:
    Cazaña-Pérez et al.. Function. 2020.pdf
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