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Título
A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum
dc.contributor.authorPérez Márquez, Lidia A.
dc.contributor.authorPerretti, Marcelle D.
dc.contributor.authorGarcía Rodríguez, Raúl 
dc.contributor.authorLahoz, Fernando
dc.contributor.authorCarrillo, Romen
dc.date.accessioned2024-02-01T13:41:18Z
dc.date.available2024-02-01T13:41:18Z
dc.date.issued2022
dc.identifier.citationAngew. Chem. Int. Ed. 2022, 61, e202205403; Angew. Chem. 2022, 134, e202205403es
dc.identifier.issn1433-7851es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/65522
dc.description.abstract3-Nitrotyrosine (NT) is generated by the action of peroxynitrite and other reactive nitrogen species (RNS), and as a consequence it is accumulated in inflammation-associated conditions. This is particularly relevant in kidney disease, where NT concentration in blood is considerably high. Therefore, NT is a crucial biomarker of renal damage, although it has been underestimated in clinical diagnosis due to the lack of an appropriate sensing method. Herein we report the first fluorescent supramolecular sensor for such a relevant compound: Fluorescence by rotational restriction of tetraphenylethenes (TPE) in a covalent cage is selectively quenched in human blood serum by 3-nitrotyrosine (NT) that binds to the cage with high affinity, allowing a limit of detection within the reported physiological concentrations of NT in chronic kidney disease.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherWileyes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectQuímica inorgánicaes
dc.subject.classificationMolecular Cageses
dc.subject.classificationlecular Recognitiones
dc.subject.classificationNitrotyrosinees
dc.subject.classificationSensors Tetraphenylethenees
dc.titleA Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serumes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/10.1002/anie.202205403es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/anie.202205403es
dc.identifier.publicationissue28es
dc.identifier.publicationtitleAngewandte Chemiees
dc.identifier.publicationvolume61es
dc.peerreviewedSIes
dc.description.projectMinisterio de Ciencia e Innovación. Grant Numbers: PGC2018-094503-B-C21, PID2019-110430GB-C21, PID2019-107335RA-I00, PGC2018-096880-A-I00es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco2301.06 Fluorimetríaes
dc.subject.unesco2301 Química Analíticaes


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