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dc.contributor.author | Alió del Barrio, Jorge L. | |
dc.contributor.author | De La Mata Sampedro, Ana | |
dc.contributor.author | De Miguel, María P. | |
dc.contributor.author | Arnalich Montiel, Francisco | |
dc.contributor.author | Nieto-Miguel, Teresa | |
dc.contributor.author | El Zarif, Mona | |
dc.contributor.author | Cadenas-Martín, Marta | |
dc.contributor.author | López-Paniagua, Marina | |
dc.contributor.author | Galindo, Sara | |
dc.contributor.author | Calonge, Margarita | |
dc.contributor.author | Alió, Jorge L. | |
dc.date.accessioned | 2024-02-02T12:13:21Z | |
dc.date.available | 2024-02-02T12:13:21Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Alió Del Barrio JL, De la Mata A, De Miguel MP, Arnalich-Montiel F, Nieto-Miguel T, El Zarif M, Cadenas-Martín M, López-Paniagua M, Galindo S, Calonge M, Alió JL. Corneal Regeneration Using Adipose-Derived Mesenchymal Stem Cells. Cells. 2022 Aug 16;11(16):2549. doi: 10.3390/cells11162549. PMID: 36010626; PMCID: PMC9406486. | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/65586 | |
dc.description.abstract | Adipose-derived stem cells are a subtype of mesenchymal stem cell that offers the important advantage of being easily obtained (in an autologous manner) from low invasive procedures, rendering a high number of multipotent stem cells with the potential to differentiate into several cellular lineages, to show immunomodulatory properties, and to promote tissue regeneration by a paracrine action through the secretion of extracellular vesicles containing trophic factors. This secretome is currently being investigated as a potential source for a cell-free based regenerative therapy for human tissues, which would significantly reduce the involved costs, risks and law regulations, allowing for a broader application in real clinical practice. In the current article, we will review the existing preclinical and human clinical evidence regarding the use of such adipose-derived mesenchymal stem cells for the regeneration of the three main layers of the human cornea: the epithelium (derived from the surface ectoderm), the stroma (derived from the neural crest mesenchyme), and the endothelium (derived from the neural crest cells). | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.title | Corneal Regeneration Using Adipose-Derived Mesenchymal Stem Cells | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.3390/cells11162549 | es |
dc.identifier.publicationfirstpage | 2549 | es |
dc.identifier.publicationissue | 16 | es |
dc.identifier.publicationtitle | Cells | es |
dc.identifier.publicationvolume | 11 | es |
dc.peerreviewed | SI | es |
dc.identifier.essn | 2073-4409 | es |
dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | es |