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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/65791

    Título
    Ca2+ entry into neurons is facilitated by cooperative gating of clustered CaV1.3 channels
    Autor
    Moreno, Claudia M
    Dixon, Rose E
    Tajada Esteban, SendoaAutoridad UVA
    Yuan, Can
    Opitz-Araya, Ximena
    Binder, Marc D
    Santana, Luis F
    Año del Documento
    2016
    Documento Fuente
    Elife. 2016 May 17;5:e15744.
    Résumé
    CaV1.3 channels regulate excitability in many neurons. As is the case for all voltage-gated channels, it is widely assumed that individual CaV1.3 channels behave independently with respect to voltage-activation, open probability, and facilitation. Here, we report the results of super-resolution imaging, optogenetic, and electrophysiological measurements that refute this long-held view. We found that the short channel isoform (CaV1.3S), but not the long (CaV1.3L), associates in functional clusters of two or more channels that open cooperatively, facilitating Ca(2+) influx. CaV1.3S channels are coupled via a C-terminus-to-C-terminus interaction that requires binding of the incoming Ca(2+) to calmodulin (CaM) and subsequent binding of CaM to the pre-IQ domain of the channels. Physically-coupled channels facilitate Ca(2+) currents as a consequence of their higher open probabilities, leading to increased firing rates in rat hippocampal neurons. We propose that cooperative gating of CaV1.3S channels represents a mechanism for the regulation of Ca(2+) signaling and electrical activity.
    Revisión por pares
    SI
    DOI
    10.7554/eLife.15744
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/65791
    Tipo de versión
    info:eu-repo/semantics/draft
    Derechos
    openAccess
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    • DEP06 - Artículos de revista [353]
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    Moreno et al. - 2016 - Ca2 entry into neurons is facilitated by cooperative gating of clustered Cav1.3 channels.pdf
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    4.930Mo
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