Show simple item record

dc.contributor.authorGhosh, Debapriya
dc.contributor.authorNieves-Cintrón, Madeline
dc.contributor.authorTajada, Sendoa
dc.contributor.authorBrust-Mascher, Ingrid
dc.contributor.authorHorne, Mary C.
dc.contributor.authorHell, Johannes W.
dc.contributor.authorDixon, Rose E.
dc.contributor.authorSantana, Luis F.
dc.contributor.authorNavedo, Manuel F.
dc.date.accessioned2024-02-06T12:29:33Z
dc.date.available2024-02-06T12:29:33Z
dc.date.issued2018
dc.identifier.citationBiochim Biophys Acta Mol Cell Res. 2018 Sep;1865(9):1341-1355.es
dc.identifier.issn0167-4889es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/65819
dc.description.abstractL-type CaV1.2 channels are key regulators of gene expression, cell excitability and muscle contraction. CaV1.2 channels organize in clusters throughout the plasma membrane. This channel organization has been suggested to contribute to the concerted activation of adjacent CaV1.2 channels (e.g. cooperative gating). Here, we tested the hypothesis that dynamic intracellular and perimembrane trafficking of CaV1.2 channels is critical for formation and dissolution of functional channel clusters mediating cooperative gating. We found that CaV1.2 moves in vesicular structures of circular and tubular shape with diverse intracellular and submembrane trafficking patterns. Both microtubules and actin filaments are required for dynamic movement of CaV1.2 vesicles. These vesicles undergo constitutive homotypic fusion and fission events that sustain CaV1.2 clustering, channel activity and cooperative gating. Our study suggests that CaV1.2 clusters and activity can be modulated by diverse and unique intracellular and perimembrane vesicular dynamics to fine-tune Ca2+ signals.es
dc.format.mimetypeapplication/pdfes
dc.language.isospaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.titleDynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gatinges
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016/J.BBAMCR.2018.06.013es
dc.identifier.publicationfirstpage1341es
dc.identifier.publicationissue9es
dc.identifier.publicationlastpage1355es
dc.identifier.publicationtitleBiochimica et Biophysica Acta (BBA) - Molecular Cell Researches
dc.identifier.publicationvolume1865es
dc.peerreviewedSIes
dc.type.hasVersioninfo:eu-repo/semantics/draftes


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record