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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/65861

    Título
    Carotid body function and ventilatory responses in intermittent hypoxia. evidence for anomalous brainstem integration of arterial chemoreceptor input
    Autor
    Gonzalez‐Martín, M.C.
    Vega Agapito, María VictoriaAutoridad UVA
    Conde, Silvia V.
    Castañeda Casado, Francisco Javier
    Bustamante Bustamante, María Rosa
    Olea Fraile, ElenaAutoridad UVA
    Perez‐Vizcaino, F.
    González Martínez, Constancio
    Obeso Cáceres, Ana María de la LuzAutoridad UVA Orcid
    Año del Documento
    2011
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Cellular Physiology, vol 226, n. 8, p1964-1969
    Resumen
    Obstructive sleep apnea is a frequent medical condition consisting in repetitive sleep-related episodes of upper airways obstruction and concurrent events of arterial blood hypoxia. There is a frequent association of cardiovascular diseases and other pathologies to this condition conforming the obstructive sleep apnea syndrome (OSAS). Laboratory models of OSAS consist in animals exposed to repetitive episodes of intermittent hypoxia (IH) which also develop cardiovascular pathologies, mostly hypertension. The overall OSAS pathophysiology appears to be linked to the repetitive hypoxia, which would cause a sensitization of carotid body (CB) chemoreflex and chemoreflex-driven hyperreactivity of the sympathetic nervous system. However, this proposal is uncertain because hyperventilation, reflecting the CB sensitization, and increased plasmaCAlevels, reflecting sympathetic hyperreactivity, are not constant findings in patients with OSAS and IH animals. Aiming to solve these uncertainties we have studied the entire CB chemoreflex arch in a rat model of IH, including activity of chemoreceptor cells and CB generated afferent activity to brainstem. The efferent activity was measured as ventilation in normoxia, hypoxia, and hypercapnia. Norepinephrine turnover in renal artery sympathetic endings was also assessed. Findings indicate a sensitization of the CB function to hypoxia evidenced by exaggerated chemoreceptor cell and CB afferent activity. Yet, IH rats exhibited marked hypoventilation in all studied conditions and increased turnover of norepinephrine in sympathetic endings. We conclude that IH produces a bias in the integration of the input arising from the CB with a diminished drive of ventilation and an exaggerated activation of brainstem sympathetic neurons.
    ISSN
    0021-9541
    Revisión por pares
    SI
    DOI
    10.1002/jcp.22528
    Patrocinador
    This work was supported by Ministry of Science and Innovation (Spain) (BFU2007-61848 and SAF2007-03948), Institute Carlos III (CIBER CB06/06/0050), and Junta de Castilla y Leon (GR242).
    Version del Editor
    https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.22528
    Propietario de los Derechos
    Wiley
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/65861
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    restrictedAccess
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    Universidad de Valladolid

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