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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/65876

    Título
    Quantification of microvascular lesions in the central retinal field: Could It predict the severity of diabetic retinopathy?
    Autor
    Fernández Carneado, Jimena
    Almazán Moga, Ana
    Ramírez Lamelas, Dolores T.
    Cuscó, Cristina
    Alonso de la Fuente, José Ignacio
    Pastor Jimeno, José CarlosAutoridad UVA
    López Gálvez, María IsabelAutoridad UVA
    Ponsati, Berta
    Año del Documento
    2023
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Journal of Clinical Medicine, 2023, Vol. 12, Nº. 12, 3948
    Abstract
    Diabetic retinopathy (DR) is a neurodegenerative disease characterized by the presence of microcirculatory lesions. Among them, microaneurysms (MAs) are the first observable hallmark of early ophthalmological changes. The present work aims to study whether the quantification of MAs, hemorrhages (Hmas) and hard exudates (HEs) in the central retinal field could have a predictive value on DR severity. These retinal lesions were quantified in a single field NM-1 of 160 retinographies of diabetic patients from the IOBA’s reading center. Samples included different disease severity levels and excluded proliferating forms: no DR (n = 30), mild non-proliferative (n = 30), moderate (n = 50) and severe (n = 50). Quantification of MAs, Hmas, and HEs revealed an increasing trend as DR severity progresses. Differences between severity levels were statistically significant, suggesting that the analysis of the central field provides valuable information on severity level and could be used as a clinical tool to assess DR grading in the eyecare routine. Even though further validation is needed, counting microvascular lesions in a single retinal field can be proposed as a rapid screening system to classify DR patients with different stages of severity according to the international classification.
    Materias (normalizadas)
    Diabetic retinopathy
    Retinopatía diabética
    Eye - Diseases
    Ojo - Enfermedades y defectos
    Diabetes - Complicaciones y secuelas
    Ophthalmology
    Microvascular
    Clinical utility
    Medical Research
    Clinical medicine
    Medicina clínica - Investigación
    Public health
    Materias Unesco
    3201.09 Oftalmología
    32 Ciencias Médicas
    3212 Salud Publica
    ISSN
    2077-0383
    Revisión por pares
    SI
    DOI
    10.3390/jcm12123948
    Version del Editor
    https://www.mdpi.com/2077-0383/12/12/3948
    Propietario de los Derechos
    © 2023 The authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/65876
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IOBA - Artículos de revista [80]
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    Universidad de Valladolid

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