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    • PRODUZIONE SCIENTIFICA
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    • Dpto. Bioquímica y Biología Molecular y Fisiología
    • DEP06 - Artículos de revista
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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/65922

    Título
    OPA1 promotes pH flashes that spread between contiguous mitochondria without matrix protein exchange
    Autor
    Santo Domingo Mayoral, JaimeAutoridad UVA Orcid
    Giacomello, Marta
    Poburko, Damon
    Scorrano, Luca
    Demaurex, Nicolas
    Año del Documento
    2013
    Editorial
    Embopress
    Descripción
    Producción Científica
    Documento Fuente
    EMBO J., Jul 2013, vol. 32, n. 13, p. 1927-40.
    Abstract
    The chemical nature and functional significance of mitochondrial flashes associated with fluctuations in mitochondrial membrane potential is unclear. Using a ratiometric pH probe insensitive to superoxide, we show that flashes reflect matrix alkalinization transients of ∼0.4 pH units that persist in cells permeabilized in ion-free solutions and can be evoked by imposed mitochondrial depolarization. Ablation of the pro-fusion protein Optic atrophy 1 specifically abrogated pH flashes and reduced the propagation of matrix photoactivated GFP (paGFP). Ablation or invalidation of the pro-fission Dynamin-related protein 1 greatly enhanced flash propagation between contiguous mitochondria but marginally increased paGFP matrix diffusion, indicating that flashes propagate without matrix content exchange. The pH flashes were associated with synchronous depolarization and hyperpolarization events that promoted the membrane potential equilibration of juxtaposed mitochondria. We propose that flashes are energy conservation events triggered by the opening of a fusion pore between two contiguous mitochondria of different membrane potentials, propagating without matrix fusion to equilibrate the energetic state of connected mitochondria.
    Palabras Clave
    Mitochondrial dynamics, mitochondrial pH, bioenergetics, mito-pHlases, Opa1
    ISSN
    0261-4189
    Revisión por pares
    SI
    DOI
    10.1038/emboj.2013.124
    Patrocinador
    Swiss National Fundation
    Ministerio de Ciencia e Innovación
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/65922
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • DEP06 - Artículos de revista [352]
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