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dc.contributor.author | León, Iker | |
dc.contributor.author | Alonso, Elena R. | |
dc.contributor.author | Mata, Santiago | |
dc.contributor.author | Cabezas, Carlos | |
dc.contributor.author | Alonso, Jose Luis | |
dc.date.accessioned | 2024-02-08T11:22:16Z | |
dc.date.available | 2024-02-08T11:22:16Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Angewandte Chemie International Edition, 2019, 58, 16002 | es |
dc.identifier.issn | 1433-7851 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/65992 | |
dc.description | Producción Científica | es |
dc.description.abstract | Neutral glutamine has been evaporated by laserablation of its solid sample to seed a rare gas carrier prior toa supersonic expansion and proved by Fourier transformmicrowave techniques. We report on three distinct neutralconformers that show a singular non-interacting and flexibleamide sidechain in contrast with the other proteinogenicaliphatic amino acids. It could explain the essential biologicalrole of glutamine as a nitrogen source, and its unique ability toform a variety of hydrogen bonds with peptide backbones.Common computational methods fail to predict the delicatebalance of intramolecular interactions controlling the geome-try of the most stable conformer. The spectroscopic data herereported can be used to benchmark novel computationalmethods in quantum chemistry. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | spa | es |
dc.publisher | WILEY-V C H VERLAG GMBH | es |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | es |
dc.subject.classification | amino acid · FTMW spectroscopy · glutamine ·non-covalent interactions · rotational spectroscopy | es |
dc.title | Unveiling the Neutral Forms of Glutamine | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim | es |
dc.identifier.doi | 10.1002/anie.201907222 | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/10.1002/anie.201907222 | es |
dc.identifier.publicationfirstpage | 16002 | es |
dc.identifier.publicationissue | 45 | es |
dc.identifier.publicationlastpage | 16007 | es |
dc.identifier.publicationtitle | Angewandte Chemie International Edition | es |
dc.identifier.publicationvolume | 58 | es |
dc.peerreviewed | SI | es |
dc.description.project | Ministerio de Ciencia e Innovación (CTQ2013-40717-P and CTQ2016-76393-P), Junta de Castilla y León (Grant VA077U16) and the European Research Council under the European Union's Seventh Framework Programme (FP/2007–2013)/ ERC-2013-SyG, Grant Agreement n. 610256 NANOCOSMOS | es |
dc.identifier.essn | 1521-3773 | es |
dc.type.hasVersion | info:eu-repo/semantics/submittedVersion | es |