• español
  • English
  • français
  • Deutsch
  • português (Brasil)
  • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Parcourir

    Tout UVaDOCCommunautésPar date de publicationAuteursSujetsTitres

    Mon compte

    Ouvrir une session

    Statistiques

    Statistiques d'usage de visualisation

    Compartir

    Voir le document 
    •   Accueil de UVaDOC
    • PUBLICATIONS SCIENTIFIQUES
    • Institutos de Investigación
    • Instituto de Biología y Genética Molecular (IBGM)
    • IBGM - Artículos de revista
    • Voir le document
    •   Accueil de UVaDOC
    • PUBLICATIONS SCIENTIFIQUES
    • Institutos de Investigación
    • Instituto de Biología y Genética Molecular (IBGM)
    • IBGM - Artículos de revista
    • Voir le document
    • español
    • English
    • français
    • Deutsch
    • português (Brasil)
    • italiano

    Exportar

    RISMendeleyRefworksZotero
    • edm
    • marc
    • xoai
    • qdc
    • ore
    • ese
    • dim
    • uketd_dc
    • oai_dc
    • etdms
    • rdf
    • mods
    • mets
    • didl
    • premis

    Citas

    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/66082

    Título
    The mitochondrial Na+/Ca2+ exchanger inhibitor CGP37157 preserves muscle structure and function to increase lifespan and healthspan in Caenorhabditis elegans
    Autor
    García Casas, PalomaAutoridad UVA
    Álvarez Illera, María Pilar
    Gómez Orte, Eva
    Cabello, Juan
    Fonteriz García, Rosalba InésAutoridad UVA Orcid
    Montero Zoccola, María TeresaAutoridad UVA Orcid
    Álvarez Martín, JavierAutoridad UVA Orcid
    Año del Documento
    2021
    Editorial
    Frontiers
    Descripción
    Producción Científica
    Documento Fuente
    Frontiers in Pharmacology, 2021, vol. 12, 695687
    Résumé
    We have reported recently that the mitochondrial Na+/Ca2+ exchanger inhibitor CGP37157 extends lifespan in Caenorhabditis elegans by a mechanism involving mitochondria, the TOR pathway and the insulin/IGF1 pathway. Here we show that CGP37157 significantly improved the evolution with age of the sarcomeric regular structure, delaying development of sarcopenia in C. elegans body wall muscle and increasing the average and maximum speed of the worms. Similarly, CGP37157 favored the maintenance of a regular mitochondrial structure during aging. We have also investigated further the mechanism of the effect of CGP37157 by studying its effect in mutants of aak-1;aak-2/AMP-activated kinase, sir-2.1/sirtuin, rsks-1/S6 kinase and daf-16/FOXO. We found that this compound was still effective increasing lifespan in all these mutants, indicating that these pathways are not involved in the effect. We have then monitored pharynx cytosolic and mitochondrial Ca2+ signalling and our results suggest that CGP37157 is probably inhibiting not only the mitochondrial Na+/Ca2+ exchanger, but also Ca2+ entry through the plasma membrane. Finally, a transcriptomic study detected that CGP37157 induced changes in lipid metabolism enzymes and a four-fold increase in the expression of ncx-6, one of the C. elegans mitochondrial Na+/Ca2+ exchangers. In summary, CGP37157 increases both lifespan and healthspan by a mechanism involving changes in cytosolic and mitochondrial Ca2+ homeostasis. Thus, Ca2+ signalling could be a promising target to act on aging.
    Materias Unesco
    2415 Biología Molecular
    Palabras Clave
    C. elegans
    CGP37157
    lifespan
    endoplasmic reticulum
    mitochondria
    sarcopenia
    ISSN
    1663-9812
    Revisión por pares
    SI
    DOI
    10.3389/fphar.2021.695687
    Patrocinador
    MICINN project BFU2017-83509-R
    MICINN project PGC 2018–094276-B-I00
    Version del Editor
    https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2021.695687/full
    Propietario de los Derechos
    © 2021 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/66082
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP06 - Artículos de revista [352]
    • IBGM - Artículos de revista [78]
    Afficher la notice complète
    Fichier(s) constituant ce document
    Nombre:
    2021-fphar-CGP.pdf
    Tamaño:
    6.619Mo
    Formato:
    Adobe PDF
    Descripción:
    Artículo principal y Datos suplementarios
    Thumbnail
    Voir/Ouvrir
    Attribution 4.0 InternacionalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution 4.0 Internacional

    Universidad de Valladolid

    Powered by MIT's. DSpace software, Version 5.10