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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/66247

    Título
    Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release from the endoplasmic reticulum by AMP-activated kinase modulators
    Autor
    Arias del Val, Jessica
    Santo Domingo Mayoral, JaimeAutoridad UVA Orcid
    García Casas, PalomaAutoridad UVA
    Álvarez Illera, María Pilar
    Núñez Galindo, Antonio
    Wiederkehr, Andreas
    Fonteriz García, Rosalba InésAutoridad UVA Orcid
    Montero Zoccola, María TeresaAutoridad UVA Orcid
    Álvarez Martín, JavierAutoridad UVA Orcid
    Año del Documento
    2019
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Cell Calcium, Enero 2019, 77, 68-76
    Resumen
    The 5' AMP-activated protein kinase (AMPK) is a nutrient-sensitive kinase that plays a key role in the control of cellular energy metabolism. We have explored here the relationship between AMPK and Ca2+ signaling by looking at the effect of an AMPK activator (A769662) and an AMPK inhibitor (dorsomorphin) on histamine induced Ca2+-release from the endoplasmic reticulum (ER) in HeLa cells. Our data show that incubation with A769662 (EC50=29 μM) inhibited histamine-induced Ca2+-release from the ER in intact cells, as well as inositol-1,4,5-trisphosphate (IP3)-induced Ca2+ release in permeabilized cells. On the contrary, dorsomorphin (EC50=0.4 μM) activated both histamine and IP3-induced Ca2+-release and reversed the effect of A769662. These results suggest a direct effect of AMPK regulation on IP3 receptor (IP3R) function. A phosphoproteomic study did not reveal changes in IP3R phosphorylation, but showed significant changes in phosphorylation of proteins placed upstream in the IP3R interactome and in several proteins related with Ca2+ metabolism, which could be candidates to mediate the effects observed. In conclusion, our data suggest that AMPK negatively regulates IP3R. This effect constitutes a novel and very important link between Ca2+ signaling and the AMPK pathway.
    Palabras Clave
    AMPK, Inositol-1,4,5-trisphosphate receptor, Ca2+ signaling, Endoplasmic reticulum, A769662, Dorsomorphin
    ISSN
    0143-4160
    Revisión por pares
    SI
    DOI
    10.1016/j.ceca.2018.12.004
    Patrocinador
    MICINN project BFU2014-55731-R
    MICINN project BFU2017-83509-R
    Version del Editor
    https://www.sciencedirect.com/science/article/pii/S014341601830160X?via%3Dihub
    Propietario de los Derechos
    Elsevier Ltd.
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/66247
    Tipo de versión
    info:eu-repo/semantics/acceptedVersion
    Derechos
    restrictedAccess
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    • DEP06 - Artículos de revista [352]
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    Arias del Val et al - Cell Calcium 2019.pdf
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    Universidad de Valladolid

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