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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/66459

    Título
    Limbic hyperactivity associated to verbal memory deficit in schizophrenia
    Autor
    Suazo, Vanessa
    Díez Revuelta, ÁlvaroAutoridad UVA
    Tamayo, Pilar
    Montes, Carlos
    Molina Rodríguez, VicenteAutoridad UVA Orcid
    Año del Documento
    2013
    Documento Fuente
    Journal of Psychiatric Research 47(6): 843-50
    Abstract
    In schizophrenia there seems to be an inefficient activation of prefrontal and hippocampal regions. Patients tend to show worse cognitive performance in functions subserved by those regions as compared to healthy controls in spite of higher regional activation. However, the association between activation abnormalities and cognitive deficits remains without being understood. In the present study, we compared cerebral perfusion using single-photon emission tomography (SPECT) in patients and controls to study the association between activation patterns and cognitive performance in this disease. The SPECT studies were simultaneously obtained with an electrophysiological recording during a P300 paradigm to elicit P3a and P3b components. We included 23 stable patients with paranoid schizophrenia and 29 healthy controls that underwent clinical and cognitive assessments. Patients with schizophrenia showed an increased perfusion in the right hippocampus with respect to healthy controls, they also displayed a statistically significant inverse association between perfusion in the left hippocampus and verbal memory performance. Healthy controls showed an inverse association between perfusion in the left dorsolateral prefrontal (DLPFC) region and working memory performance. P3b but not P3a amplitude was significantly lower in patients. The limbic overactivation in the patients may contribute to their cognitive deficits in verbal memory.
    ISSN
    0022-3956
    Revisión por pares
    SI
    DOI
    10.1016/j.jpsychires.2013.02.007
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/66459
    Tipo de versión
    info:eu-repo/semantics/draft
    Derechos
    openAccess
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    • DEP55 - Artículos de revista [206]
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    Universidad de Valladolid

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