Increased release of [3H]dopamine during low O2 stimulation of rabbit carotid body in vitro

González, Constancio; Fidone, Salvatore

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Título

Increased release of [3H]dopamine during low O2 stimulation of rabbit carotid body in vitro

Autor

González, Constancio

Fidone, Salvatore

Año del Documento

1977

Editorial

Elsevier

Descripción

Producción Científica

Documento Fuente

Neuroscience Letters, 6(1977) 95-99

Resumen

Rabbit carotid bodies synthesized [3H]dopamine (DA) during a 3-h incubation period in modified Tyrode's solution containing 40 uM [3H]tyrosine. Following tbis loading period, the carotid bodies were exposed for one additional hour to unlabelled Tyrode's solution equilibrated with either 10% oxygen in nitrogen or with 100% oxygen. The carotid bodies exposed to low O2 released 81% more [3H]dopamine during this one-hour period than the carotid bodies exposed only to pure oxygen. These data suggest that hypoxia induces release of DA from the carotid body.

Materias (normalizadas)

Cuerpo carótido

Tiróides - Enfermedades

ISSN

0304-3940

Revisión por pares