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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/68879

    Título
    Intravitreal stem cell paracrine properties as a potential neuroprotective therapy for retinal photoreceptor neurodegenerative diseases
    Autor
    Fernández Bueno, IvánAutoridad UVA
    Puertas Neyra, Kevin LouisAutoridad UVA Orcid
    Usategui Martín, RicardoAutoridad UVA Orcid
    Coco Martín, Rosa MaríaAutoridad UVA Orcid
    Año del Documento
    2020-09
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Neural Regen Res, Sep, 2020, vol.15, n. 9, p.1631-1638.
    Resumen
    Abstract: Retinal degenerations are the leading causes of irreversible visual loss worldwide. Many pathologies included under this umbrella involve progressive degeneration and ultimate loss of the photoreceptor cells, with age-related macular degeneration and inherited and ischemic retinal diseases the most relevant. These diseases greatly impact patients’ daily lives, with accompanying marked social and economic consequences. However, the currently available treatments only delay the onset or slow progression of visual impairment, and there are no cures for these photoreceptor diseases. Therefore, new therapeutic strategies are being investigated, such as gene therapy, optogenetics, cell replacement, or cell-based neuroprotection. Specifically, stem cells can secrete neurotrophic, immunomodulatory, and anti-angiogenic factors that potentially protect and preserve retinal cells from neurodegeneration. Further, neuroprotection can be used in different types of retinal degenerative diseases and at different disease stages, unlike other potential therapies. This review summarizes stem cell-based paracrine neuroprotective strategies for photoreceptor degeneration, which are under study in clinical trials, and the latest preclinical studies. Effective retinal neuroprotection could be the next frontier in photoreceptor diseases, and the development of novel neuroprotective strategies will address the unmet therapeutic needs.
    Materias (normalizadas)
    32 CIENCIAS MEDICAS; 3201: Ciencias clínicas; 320109: Oftalmología
    Materias Unesco
    3201.09 Oftalmología
    Palabras Clave
    clinical trials; growth factors; intraocular injection; intravitreal injection; neuroprotection; paracrine properties; photoreceptors; preclinical models; retinal diseases; stem cells
    ISSN
    1673-5374
    Revisión por pares
    SI
    DOI
    10.4103/1673-5374.276324
    Version del Editor
    https://journals.lww.com/nrronline/fulltext/2020/15090/intravitreal_stem_cell_paracrine_properties_as_a.7.aspx
    Propietario de los Derechos
    Wolters Kluwer Health
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/68879
    Tipo de versión
    info:eu-repo/semantics/acceptedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • Retina - Artículos de Revista [13]
    • IOBA - Artículos de revista [80]
    • DEP11 - Artículos de revista [242]
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    Universidad de Valladolid

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