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dc.contributor.authorMedina Polo, José
dc.contributor.authorFalkensammer, Eva
dc.contributor.authorKöves, Béla
dc.contributor.authorKranz, Jennifer
dc.contributor.authorTandogdu, Zafer
dc.contributor.authorTapia Herrero, Ana María
dc.contributor.authorCai, Tommaso
dc.contributor.authorWagenlehner, Florian M. E.
dc.contributor.authorSchneidewind, Laila
dc.contributor.authorBjerklund Johansen, Truls Erik
dc.date.accessioned2024-10-02T08:03:41Z
dc.date.available2024-10-02T08:03:41Z
dc.date.issued2024
dc.identifier.citationAntibiotics, 2024, Vol. 13, Nº. 5, 442es
dc.identifier.issn2079-6382es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/70300
dc.descriptionProducción Científicaes
dc.description.abstract(1) Background: Urinary tract infections (UTIs) are among the most frequent complications in kidney transplant (KT) recipients. Asymptomatic bacteriuria (ASB) may be a risk factor for UTIs and graft rejection. We aimed to evaluate available evidence regarding the benefit of screening and treatment of ASB within the first year after KT. (2) Evidence acquisition: A systematic literature search was conducted in MEDLINE, the Cochrane Library CENTRAL and Embase. Inclusion criteria were manuscripts in English addressing the management of ASB after KT. The PICO questions concerned Patients (adults receiving a KT), Intervention (screening, diagnosis and treatment of ASB), Control (screening and no antibiotic treatment) and Outcome (UTIs, sepsis, kidney failure and death). (3) Evidence synthesis: The systematic review identified 151 studies, and 16 full-text articles were evaluated. Seven were excluded because they did not evaluate the effect of treatment of ASB. There was no evidence for a higher incidence of lower UTIs, acute pyelonephritis, graft loss, or mortality in patients not treated with antibiotics for ASB. Analysis of comparative non-randomized and observational studies did not provide supplementary evidence to guide clinical recommendations. We believe this lack of evidence is due to confounding risk factors that are not being considered in the stratification of study patients.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherMDPIes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAntibioticses
dc.subjectAntibióticoses
dc.subjectUrologic diseaseses
dc.subjectUrinario, Aparato - Enfermedades - Tratamientoes
dc.subjectUrologyes
dc.subjectNephrologyes
dc.subjectKidneys - Diseaseses
dc.subjectRiñones - Enfermedadeses
dc.subjectKidneys - Transplantationes
dc.subjectRiñones - Trasplantees
dc.subjectUrinary tract infectionses
dc.subjectVías urinarias - Infeccioneses
dc.subjectInsuficiencia renal agudaes
dc.subjectAcute renal failurees
dc.subjectMeta-analysises
dc.subjectSystematic reviews (Medical research)es
dc.subjectMedicina - Investigaciónes
dc.subjectPublic healthes
dc.titleSystematic review and meta-analysis provide no guidance on management of asymptomatic bacteriuria within the first year after kidney transplantationes
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2024 The authorses
dc.identifier.doi10.3390/antibiotics13050442es
dc.relation.publisherversionhttps://www.mdpi.com/2079-6382/13/5/442es
dc.identifier.publicationfirstpage442es
dc.identifier.publicationissue5es
dc.identifier.publicationtitleAntibioticses
dc.identifier.publicationvolume13es
dc.peerreviewedSIes
dc.identifier.essn2079-6382es
dc.rightsAtribución 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones
dc.subject.unesco3213.16 Urologíaes
dc.subject.unesco3205.06 Nefrologíaes
dc.subject.unesco32 Ciencias Médicases
dc.subject.unesco3212 Salud Publicaes


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