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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/70607

    Título
    Phenotypic characterization of acute headache attributed to SARS-CoV-2: An ICHD-3 validation study on 106 hospitalized patients
    Autor
    Trigo López, Javier
    García Azorín, DavidAutoridad UVA Orcid
    Planchuelo Gómez, ÁlvaroAutoridad UVA Orcid
    García Iglesias, Cristina
    Dueñas Gutiérrez, Carlos JesúsAutoridad UVA
    Guerrero Peral, Angel LuisAutoridad UVA Orcid
    Año del Documento
    2020
    Editorial
    SAGE Publications
    Documento Fuente
    Cephalalgia 2020, vol. 40, n.13, p. 1432-1442
    Resumo
    Introduction: Headache is a common symptom of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this study, we aimed to characterize the phenotype of headache attributed to SARS-CoV-2 infection and to test the International Classification of Headache Disorders (ICHD-3) phenotypic criteria for migraine and tension-type headache. Methods: The study design was a cross-sectional study nested in a cohort. We screened all consecutive patients that were hospitalized and had a positive SARS-CoV-2 test. We included patients that described headache if the headache was not better explained by another ICHD-3 diagnosis. Patients were interviewed by two neurologists. Results: We screened 580 patients and included 130 (mean age 56 years, 64% female). Headache was the first symptom of the infection in 26% of patients and appeared within 24 hours in 62% of patients. The headache was bilateral in 85%, frontal in 83%, and with pressing quality in 75% of patients. Mean intensity was 7.1, being severe in 64%. Hypersensitivity to stimuli occurred in 57% of patients. ICHD-3 criteria for headache attributed to systemic viral infection were fulfilled by 94% of patients; phenotypic criteria for migraine were fulfilled by 25% of patients, and tension-type headache criteria by 54% of patients. Conclusion: Headache attributed to SARS-CoV-2 infection in hospitalized patients has severe intensity, frontal predominance and oppressive quality. It occurs early in the course of the disease. Most patients fulfilled ICHD-3 criteria for headache attributed to systemic viral infection; however, the phenotype might resemble migraine in a quarter of cases and tension-type headache in half of the patients.
    Palabras Clave
    COVID-19
    Headache disorders
    Migraine disorders
    Nervous system diseases
    Secondary
    Tension-type headache
    ISSN
    0333-1024
    Revisión por pares
    SI
    DOI
    10.1177/0333102420965146
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/70607
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    trigo-lopez-et-al-2020-phenotypic-characterization-of-acute-headache-attributed-to-sars-cov-2-an-ichd-3-validation.pdf
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    Universidad de Valladolid

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