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dc.contributor.authorGonzález, Constancio
dc.contributor.authorSanz Alfayate, Gloria
dc.contributor.authorAgapito Serrano, María Teresa
dc.contributor.authorGómez Niño, María Ángeles 
dc.contributor.authorRocher Martín, María Asunción 
dc.contributor.authorObeso Cáceres, Ana María de la Luz 
dc.date.accessioned2014-11-17T08:45:18Z
dc.date.available2014-11-17T08:45:18Z
dc.date.issued2002
dc.identifier.citationRespiratory Physiology & Neurobiology 132 (2002) 17–41es
dc.identifier.issn1569-9048es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/7168
dc.description.abstractReactive oxygen species (ROS) are oxygen-containing molecular entities which are more potent and effective oxidizing agents than is molecular oxygen itself. With the exception of phagocytic cells, where ROS play an important physiological role in defense reactions, ROS have classically been considered undesirable byproducts of cell metabolism, existing several cellular mechanisms aimed to dispose them. Recently, however, ROS have been considered important intracellular signaling molecules, which may act as mediators or second messengers in many cell functions. This is the proposed role for ROS in oxygen sensing in systems, such as carotid body chemoreceptor cells, pulmonary artery smooth muscle cells, and erythropoietin-producing cells. These unique cells comprise essential parts of homeostatic loops directed to maintain oxygen levels in multicellular organisms in situations of hypoxia. The present article examines the possible significance of ROS in these three cell systems, and proposes a set of criteria that ROS should satisfy for their consideration as mediators in hypoxic transduction cascades. In none of the three cell types do ROS satisfy these criteria, and thus it appears that alternative mechanisms are responsible for the transduction cascades linking hypoxia to the release of neurotransmitters in chemoreceptor cells, contraction in pulmonary artery smooth muscle cells and erythropoietin secretion in erythropoietin producing cells.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNeurofisiologíaes
dc.titleSignificance of ROS in oxygen sensing in cell systems with sensitivy to ohysiological hypoxiaes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016/S1569-9048(02)00047-2
dc.identifier.publicationfirstpage17es
dc.identifier.publicationlastpage41es
dc.identifier.publicationtitleRespiratory Physiology & Neurobiologyes
dc.identifier.publicationvolume132es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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