13.02 - Oxepanes and Oxepines

Abstract

Seven-membered rings oxacycles are motifs abundant in natural products with interesting biological properties. The literature contains a myriad of works focused on synthetic routes to achieve this type of skeleton that thermodynamically is less favored than five or six members’ counterparts. This article aims at illustrating the main strategies addressed to master the synthesis of oxepanes and oxepines reviewing the works published in the field between 2008 and 2020.