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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/74252

    Título
    Putrescine modulation of acute activation of the β-adrenergic system in the left atrium of rat
    Autor
    Bordallo, Carmen
    Cantabrana, Begoña
    Velasco, Lucía
    Secades, Lorena
    Meana González, ClaraAutoridad UVA Orcid
    Méndez, Miriam
    Bordallo, Javier
    Sánchez, Manuel
    Año del Documento
    2008
    Documento Fuente
    European Journal of Pharmacology, noviembre 2008, vol. 598, n. 1-3, p. 68-74
    Resumen
    Endogenous polyamines mediate acute metabolic effects and cardiac hypertrophy associated to β-adrenoceptor stimulation. The aim of this study is to characterize the role of polyamines on β-adrenoceptor system mediated responses. To this end, the functional interaction of polyamine modifying drugs on isoproterenol-elicited cardiotonic effect, in isolated left atria of male Wistar rats, and their effects on [3H]dihydroalprenolol (DHA) binding on β-adrenoceptors and on adenylyl cyclase activity of membrane heart were studied. Polyamines interact with β-adrenoceptors in rat heart, as shown by the displacement of [3H]DHA binding. Furthermore, putrescine (but not spermidine or spermine) increased adenylyl cyclase activity, elicited a positive inotropism and increased intracellular cAMP. The putrescine effect on adenylyl cyclase was not antagonized by the β-adrenoceptors blockers, alprenolol and ICI-118,551, and facilitated the isoproterenol effect. Neither alprenolol, atenolol nor ICI-118,551 antagonized putrescine-elicited positive inotropism.However, the effectwas abolished in preparations with desensitized β-adrenoceptors. α-Difluoromethylornithine, an inhibitor of ornithine decarboxylase, antagonized the effect of isoproterenol on inotropism and cAMP increase. In addition, putrescine might elicit effects by mechanisms independent of β-adrenoceptor system, since in left atria with functional desensitized receptors an interactionwith ouabain-elicited cardiotonic effectwas observed. These results suggest that putrescine may act as a lowaffinity agonist on β-adrenoceptors and modulate acute responses mediated by β-adrenoceptors. These findings may be of importance in the physiology and in diseases involving cardiac β-adrenoceptors.
    ISSN
    0014-2999
    Revisión por pares
    SI
    DOI
    10.1016/j.ejphar.2008.07.069
    Idioma
    spa
    URI
    https://uvadoc.uva.es/handle/10324/74252
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • DEP55 - Artículos de revista [206]
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    Nombre:
    02. 2008, EJP. Putrescine modulation of acute activation of the b-adrenergicsystem in the left atrium of rat.pdf
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    Universidad de Valladolid

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