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Título
Cell therapy using extraocular cells: mesenchymal stem cells
Autor
Año del Documento
2019
Editorial
Springer Nature
Descripción
Producción Científica
Documento Fuente
Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. (2019). Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. 2019, p. 231-262 .
Resumo
Extraocular mesenchymal stem cells (MSCs) represent an available, non-immunogenic source of stem cells that has proved to possess a potential therapeutic value in corneal epithelium regeneration based on results obtained in both preclinical and clinical studies. All published studies have revealed promising results in animal models and have shown significant corneal regeneration, improved corneal transparency and a rapid healing process associated with the restoration of vision. However, the studies performed to unravel the mechanisms underlying the beneficial effects of MSCs on the damaged ocular surface have shown that multiple mechanisms might contribute simultaneously to their therapeutic action. Although it remains uncertain if MSCs can transdifferentiate into corneal epithelial cells, these cells have shown a capacity of secreting trophic and growth factors capable of stimulating resident stem cells and reducing tissue injury, an ability to exert anti-inflammatory and immunomodulatory effects, and a capability to migrate into injured tissues. This book chapter is specifically focused on the preclinical and clinical advancements on the use of extraocular MSCs for corneal epithelium regeneration.
Materias Unesco
2410 Biología Humana
2407 Biología Celular
3201.09 Oftalmología
Palabras Clave
Cornea
Ocular surface
Cell therapy
Mesenchymal stem cells
Regeneration
ISBN
978-3-030-01304-2
Patrocinador
This work was funded by: Carlos III National Institute of Health, Spain (CIBER-BBN, CB06/01/003 MINECO/FEDER; Spanish Network on Cell Therapy, TerCel RD12/0019/0036); Ministry of Economy and Competitiveness and European Regional Development Fund, Spain (SAF2015-63594-R MINECO/FEDER, EU); Regional Center for Regenerative Medicine and Cell Therapy, Castilla y León, Spain.
Version del Editor
Propietario de los Derechos
Copyright © 2019, Springer Nature Switzerland AG
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
embargoedAccess
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