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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/75613

    Título
    Cell therapy using extraocular cells: mesenchymal stem cells
    Autor
    Nieto Miguel, TeresaAutoridad UVA Orcid
    Galindo de la Rosa, SaraAutoridad UVA Orcid
    López Paniagua, MarinaAutoridad UVA Orcid
    Pérez Soto, María InmaculadaAutoridad UVA
    Herreras Cantalapiedra, José MaríaAutoridad UVA Orcid
    Calonge, MargaritaAutoridad UVA Orcid
    Año del Documento
    2019
    Editorial
    Springer Nature
    Descripción
    Producción Científica
    Documento Fuente
    Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. Nieto-Miguel, T., Galindo, S., López-Paniagua, M., Pérez, I., Herreras, J.M., Calonge, M. (2019). Cell Therapy Using Extraocular Mesenchymal Stem Cells. In: Alió, J., Alió del Barrio, J., Arnalich-Montiel, F. (eds) Corneal Regeneration . Essentials in Ophthalmology. Springer, Cham. 2019, p. 231-262 .
    Resumo
    Extraocular mesenchymal stem cells (MSCs) represent an available, non-immunogenic source of stem cells that has proved to possess a potential therapeutic value in corneal epithelium regeneration based on results obtained in both preclinical and clinical studies. All published studies have revealed promising results in animal models and have shown significant corneal regeneration, improved corneal transparency and a rapid healing process associated with the restoration of vision. However, the studies performed to unravel the mechanisms underlying the beneficial effects of MSCs on the damaged ocular surface have shown that multiple mechanisms might contribute simultaneously to their therapeutic action. Although it remains uncertain if MSCs can transdifferentiate into corneal epithelial cells, these cells have shown a capacity of secreting trophic and growth factors capable of stimulating resident stem cells and reducing tissue injury, an ability to exert anti-inflammatory and immunomodulatory effects, and a capability to migrate into injured tissues. This book chapter is specifically focused on the preclinical and clinical advancements on the use of extraocular MSCs for corneal epithelium regeneration.
    Materias Unesco
    2410 Biología Humana
    2407 Biología Celular
    3201.09 Oftalmología
    Palabras Clave
    Cornea
    Ocular surface
    Cell therapy
    Mesenchymal stem cells
    Regeneration
    ISBN
    978-3-030-01304-2
    Patrocinador
    This work was funded by: Carlos III National Institute of Health, Spain (CIBER-BBN, CB06/01/003 MINECO/FEDER; Spanish Network on Cell Therapy, TerCel RD12/0019/0036); Ministry of Economy and Competitiveness and European Regional Development Fund, Spain (SAF2015-63594-R MINECO/FEDER, EU); Regional Center for Regenerative Medicine and Cell Therapy, Castilla y León, Spain.
    Version del Editor
    https://doi.org/10.1007/978-3-030-01304-2_17
    Propietario de los Derechos
    Copyright © 2019, Springer Nature Switzerland AG
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/75613
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    embargoedAccess
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    2019 Nieto-Miguel et al. Springer Nature book chapter_Cell therapy using extraocular mesenchymal stem cells.pdfEmbargado hasta: 9999-09-09
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    Universidad de Valladolid

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