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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/76933

    Título
    Unbiased immunome characterisation correlates with COVID-19 mRNA vaccine failure in immunocompromised adults
    Autor
    H-Vázquez, Juan
    Cal-Sabater, Paloma
    Arribas-Rodríguez, Elisa
    Fiz-López, Aida
    Perez-Segurado, Candido
    Martín-Muñoz, Álvaro
    De Prado, Ángel
    Perez Mazzali, Marina
    de Castro, Carolina G.
    del Hierro, Alejandro G.
    de la Fuente Graciani, Ignacio
    Pérez González, Sonia
    Gutiérrez, Sara
    Tellería, Pablo
    Novoa, Cristina
    Rojo Rello, SilviaAutoridad UVA Orcid
    Garcia-Blesa, Antonio
    Sedano, Rosa
    Martínez García, Ana María
    Garcinuño Pérez, Sonsoles
    Domínguez-Gil, Marta
    Hernán García, CristinaAutoridad UVA
    Guerra, Ma Mercedes
    Muñoz-Sánchez, Eduardo
    Barragan-Pérez, Cristina
    Diez Morales, Soraya
    Casazza Donnarumma, Oriana
    Ramos Pollo, Daniel
    Santamarta Solla, Natalia
    Álvarez Manzanares, Paula Ma
    Bravo, Sara
    García Alonso, Cristina
    Avendaño Fernández, Luis Alberto
    Gay Alonso, Jenifer
    Garrote, José A.
    Arranz, Eduardo
    Eiros, José María
    Rescalvo Santiago, Fernando
    Quevedo Villegas, Carolina
    Tamayo, Eduardo
    Orduña, Antonio
    Dueñas, Carlos
    Peñarrubia, María Jesús
    Cuesta-Sancho, Sara
    Montoya, María
    Bernardo, David
    Año del Documento
    2024
    Editorial
    Frontiers in Immunology
    Descripción
    Producción Científica
    Documento Fuente
    Frontiers in Immunology, November, 2024, Sec. Viral Immunology Volume 15 - 2024 |
    Resumo
    Introduction: Coronavirus disease 2019 (COVID-19) affects the population unequally, with a greater impact on older and immunosuppressed people. Methods: Hence, we performed a prospective experimental cohort study to characterise the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in immune-compromised patients (older adults and oncohaematologic patients), compared with healthy counterparts, based on deep characterisation of the circulating immune cell subsets. Results and discussion: While acquired humoral and cellular memory did not predict subsequent infection 18 months after full vaccination, spectral and computational cytometry revealed several subsets within the CD8+ T-cells, B-cells, natural killer (NK) cells, monocytes and TEMRA Tγδ cells that were differentially expressed in individuals who were subsequently infected and not infected not just following immunisation, but also prior to vaccination. Of note, we found up to seven clusters within the TEMRA Tγδ cell population, with some of them being expanded and others decreased in subsequently infected individuals. Moreover, some of these cellular clusters were also related to COVID-19-induced hospitalisation in oncohaematologic patients. Therefore, we have identified a cellular signature that even before vaccination is related to COVID-19 vulnerability as opposed to the acquisition of cellular and/or humoral memory following vaccination with SARS-CoV-2 messenger RNA (mRNA) vaccines.
    Materias (normalizadas)
    Covid-19 (Enfermedad)
    Inmunología
    Materias Unesco
    2412 Inmunología
    Palabras Clave
    Computational cytometry
    Vaccine failure
    COVID-19
    Immunocompromised adult
    ISSN
    1664-3224
    Revisión por pares
    SI
    DOI
    10.3389/fimmu.2024.1405217
    Patrocinador
    Proyectos COVID 07.04.467B04.74011.0 and IR2020-1-UVA01, Junta de Castilla y León (Spain)
    European Commission \u2013NextGenerationEU (Regulation EU 2020/2094), through CSIC\u2019s Global Health Platform (PTI Salud Global: SGL21-03-026, SGL2021-03-038, COVID-19-117 and SGL2103015)
    Version del Editor
    https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1405217
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/76933
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
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    • DEP55 - Artículos de revista [213]
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    Unbiased immunome characterisation correlates with COVID-19 mRNA vaccine failure in immunocompromised adults.pdf
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