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Título
Unbiased immunome characterisation correlates with COVID-19 mRNA vaccine failure in immunocompromised adults
Autor
Año del Documento
2024
Editorial
Frontiers in Immunology
Descripción
Producción Científica
Documento Fuente
Frontiers in Immunology, November, 2024, Sec. Viral Immunology Volume 15 - 2024 |
Resumo
Introduction: Coronavirus disease 2019 (COVID-19) affects the population unequally, with a greater impact on older and immunosuppressed people.
Methods: Hence, we performed a prospective experimental cohort study to characterise the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in immune-compromised patients (older adults and oncohaematologic patients), compared with healthy counterparts, based on deep characterisation of the circulating immune cell subsets.
Results and discussion: While acquired humoral and cellular memory did not predict subsequent infection 18 months after full vaccination, spectral and computational cytometry revealed several subsets within the CD8+ T-cells, B-cells, natural killer (NK) cells, monocytes and TEMRA Tγδ cells that were differentially expressed in individuals who were subsequently infected and not infected not just following immunisation, but also prior to vaccination. Of note, we found up to seven clusters within the TEMRA Tγδ cell population, with some of them being expanded and others decreased in subsequently infected individuals. Moreover, some of these cellular clusters were also related to COVID-19-induced hospitalisation in oncohaematologic patients. Therefore, we have identified a cellular signature that even before vaccination is related to COVID-19 vulnerability as opposed to the acquisition of cellular and/or humoral memory following vaccination with SARS-CoV-2 messenger RNA (mRNA) vaccines.
Materias (normalizadas)
Covid-19 (Enfermedad)
Inmunología
Materias Unesco
2412 Inmunología
Palabras Clave
Computational cytometry
Vaccine failure
COVID-19
Immunocompromised adult
ISSN
1664-3224
Revisión por pares
SI
Patrocinador
Proyectos COVID 07.04.467B04.74011.0 and IR2020-1-UVA01, Junta de Castilla y León (Spain)
European Commission \u2013NextGenerationEU (Regulation EU 2020/2094), through CSIC\u2019s Global Health Platform (PTI Salud Global: SGL21-03-026, SGL2021-03-038, COVID-19-117 and SGL2103015)
European Commission \u2013NextGenerationEU (Regulation EU 2020/2094), through CSIC\u2019s Global Health Platform (PTI Salud Global: SGL21-03-026, SGL2021-03-038, COVID-19-117 and SGL2103015)
Version del Editor
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
Aparece en las colecciones
Arquivos deste item
Tamaño:
6.127Mb
Formato:
Adobe PDF

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