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Título
Organocatalytic Enantioselective Synthesis of Oxindole‐4‐Aminopyrazolone Derivatives via Mannich Reaction of 3‐Substituted Oxindoles With Pyrazolinone Ketimines
dc.contributor.authorMolinero, María E.
dc.contributor.authorTejedor, Sandra
dc.contributor.authorMartín Maroto, Laura 
dc.contributor.authorMaestro Fernández, Alicia 
dc.contributor.authorAndrés García, José María 
dc.date.accessioned2025-10-08T11:21:14Z
dc.date.available2025-10-08T11:21:14Z
dc.date.issued2025
dc.identifier.citationJournal of Heterocyclic Chemistry, 2025, vol. 62, p. 496-504.es
dc.identifier.issn0022-152Xes
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/78449
dc.descriptionProducción Científicaes
dc.description.abstractThe organocatalyzed Mannich reaction between pyrazolinone ketimines and 3-aryl-substituted oxindoles mediated by a hidroquinine-derived squaramide is reported. This method enables the synthesis of a diverse set of oxindole-4-aminopyrazolone derivatives bearing vicinal tetrasubstituted stereocenters, affording products in good yields (up to 95%), with excellent diastereoselectivity (> 20:1) and moderate enantioselectivity (up to 85:15 er) under mild conditions.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherWileyes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectOrganocatálisis asimétricaes
dc.subjectAdición de Manniches
dc.subjectOxindoles
dc.subjectCetiminas derivadas de pirazolinonaes
dc.subjectCentros estereogénicos cuaternarioses
dc.titleOrganocatalytic Enantioselective Synthesis of Oxindole‐4‐Aminopyrazolone Derivatives via Mannich Reaction of 3‐Substituted Oxindoles With Pyrazolinone Ketimineses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2025 The Author(s)es
dc.identifier.doi10.1002/jhet.70005es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/epdf/10.1002/jhet.70005es
dc.identifier.publicationfirstpage496es
dc.identifier.publicationissue8es
dc.identifier.publicationlastpage504es
dc.identifier.publicationtitleJournal of Heterocyclic Chemistryes
dc.identifier.publicationvolume62es
dc.peerreviewedSIes
dc.description.projectJunta de Castilla y León (VA072G24)es
dc.description.projectOpen access funding provided by FEDER European Funds and the Junta De Castilla y León under the Research and Innovation Strategy for Smart Specialization (RIS3) of Castilla y León 2021-2027.es
dc.identifier.essn1943-5193es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersiones


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