Homogeneous catalysis in continuous flow. Metal and organo-catalysis

Abstract

The integration of homogeneous catalytic methodologies in continuous flow have provided during the last decades new synthetic opportunities for organic chemists. A plethora of organocatalytic and transition-metal catalyzed transformations has been described to access to underexplored chemical space and have improved reaction times and selectivities to custom complex small molecules. These chemical approaches have been also described for the preparation of active pharmaceutical ingredients (APIs) not only for specific organic scaffolds but also in scale-up versions of valuable molecules.