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Título
Validation of an experimental animal model for corneal additive surgery
Autor
Año del Documento
2014
Editorial
OMICS Publishing Group
Descripción
Producción Científica
Documento Fuente
J Clin Exp Ophthalmol, 2014, vol. 5, no 360
Resumen
Purpose: To assess the hen cornea as a model for training and future wound healing studies after implantation
of intrastromal corneal ring segments (ICRS) by clinical and optical outcomes.
Setting: University of Valladolid, Valladolid, Spain.
Design: Experimental study.
Methods: One 90°, 150-μm thick polymethyl methacrylate Ferrara ICRS segment was manually implanted at
70-80% depth of 192 Gallus domesticus corneas. Clinical follow-up for 6 months included monitoring corneal
thickness, epithelial wound closure, edema, haze, and the location and severity of deposits. The refractive state was
also measured. After each animal was euthanized, corneas were processed for direct transmittance and histological
analysis.
Results: Complications were present in 16% of the eyes. Epithelial wound closure was completed at 3 ± 2 days.
A slight corneal edema in the channel site was present for the first 15 days. All corneas had deposits by 4 months
located along the inner, outer curvatures and under the segments. Corneal haze was present only at the incision
site. ICRS induced hyperopic changes in the refractive state without changes in direct transmitance of central
cornea. New cells and extracellular matrix were present around the segment where deposits were seen on clinical
follow-up.
Conclusions: With hen as an animal model, ICRS were implanted in a precise and reproducible way after a
learning curve. Similar to humans, the follow-up period during the first 6 months after implantation showed fast
wound closure, deposits, and haze at the incision site. ICRS in hens also reduced the refractive power withoutaffecting the central cornea.
Materias (normalizadas)
Cirugía oftalmológica
ISSN
2155-9570
Revisión por pares
SI
Idioma
eng
Derechos
openAccess
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