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dc.contributor.authorFuente García, Miguel Ángel de la 
dc.contributor.authorKumar, Lalit
dc.contributor.authorLu, Bao
dc.contributor.authorGeha, Raif S.
dc.date.accessioned2015-03-24T10:24:59Z
dc.date.available2015-03-24T10:24:59Z
dc.date.issued2006
dc.identifier.citationMolecular and Cellular Biology, 2006, vol. 26, n. 14. p. 5214–5225es
dc.identifier.issn0270-7306es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/9828
dc.descriptionProducción Científicaes
dc.description.abstractThe adapter protein 3BP2 is expressed in lymphocytes; binds to Syk/ZAP-70, Vav, and phospholipase C-γ (PLC-γ); and is thought to be important for interleukin-2 gene transcription in T cells. To define the role of 3BP2 in lymphocyte development and function, we generated 3BP2-deficient mice. T-cell development, proliferation, cytokine secretion, and signaling in response to T-cell receptor (TCR) ligation were all normal in 3BP2−/− mice. 3BP2−/− mice had increased accumulation of pre-B cells in the bone marrow and a block in the progression of transitional B cells in the spleen from the T1 to the T2 stage, but normal numbers of mature B cells. B-cell proliferation, cell cycle progression, PLC-γ2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and Erk and Jnk activation in response to B-cell receptor (BCR) ligation were all impaired. These results suggest that 3BP2 is important for BCR, but not for TCR signaling.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherAmerican Society for Microbiologyes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBiología celulares
dc.title3BP2 Deficiency impairs the response of B cells, but not T cells, to antigen receptor ligationes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1128/MCB.00087-06es
dc.identifier.doi10.1128/MCB.00087-06
dc.relation.publisherversionhttps://mcb.asm.org/content/26/14/5214.long
dc.identifier.publicationfirstpage5214es
dc.identifier.publicationissue14es
dc.identifier.publicationlastpage5225es
dc.identifier.publicationtitleMolecular and Cellular Biologyes
dc.identifier.publicationvolume26es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 3.0 International


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