dc.contributor.author | Fuente García, Miguel Ángel de la | |
dc.contributor.author | Kumar, Lalit | |
dc.contributor.author | Lu, Bao | |
dc.contributor.author | Geha, Raif S. | |
dc.date.accessioned | 2015-03-24T10:24:59Z | |
dc.date.available | 2015-03-24T10:24:59Z | |
dc.date.issued | 2006 | |
dc.identifier.citation | Molecular and Cellular Biology, 2006, vol. 26, n. 14. p. 5214–5225 | es |
dc.identifier.issn | 0270-7306 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/9828 | |
dc.description | Producción Científica | es |
dc.description.abstract | The adapter protein 3BP2 is expressed in lymphocytes; binds to Syk/ZAP-70, Vav, and phospholipase C-γ (PLC-γ); and is thought to be important for interleukin-2 gene transcription in T cells. To define the role of 3BP2 in lymphocyte development and function, we generated 3BP2-deficient mice. T-cell development, proliferation, cytokine secretion, and signaling in response to T-cell receptor (TCR) ligation were all normal in 3BP2−/− mice. 3BP2−/− mice had increased accumulation of pre-B cells in the bone marrow and a block in the progression of transitional B cells in the spleen from the T1 to the T2 stage, but normal numbers of mature B cells. B-cell proliferation, cell cycle progression, PLC-γ2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and Erk and Jnk activation in response to B-cell receptor (BCR) ligation were all impaired. These results suggest that 3BP2 is important for BCR, but not for TCR signaling. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | American Society for Microbiology | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Biología celular | es |
dc.title | 3BP2 Deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1128/MCB.00087-06 | es |
dc.identifier.doi | 10.1128/MCB.00087-06 | |
dc.relation.publisherversion | https://mcb.asm.org/content/26/14/5214.long | |
dc.identifier.publicationfirstpage | 5214 | es |
dc.identifier.publicationissue | 14 | es |
dc.identifier.publicationlastpage | 5225 | es |
dc.identifier.publicationtitle | Molecular and Cellular Biology | es |
dc.identifier.publicationvolume | 26 | es |
dc.peerreviewed | SI | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 3.0 International |
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