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oai:uvadoc.uva.es:10324/103792021-06-23T09:48:56Zcom_10324_1133com_10324_931com_10324_894col_10324_1209

CD84 leukocyte antigen is a new member of the Ig superfamily Fuente García, Miguel Ángel de la Pizcueta, Pilar Nadal, Marga Bosch, Jaime Engel, Pablo Hematología Células hematopoyéticas Producción Científica cDNA isolated from a human B-cell line Raji library was ana- (CD48 and HumLy9) have been mapped. CD84 monoclonal lyzed and shown to encode the full-length cDNA sequence antibodies (MoAbs) were shown to react with cells transof a novel cell-surface glycoprotein, initially termed HLy9-b. fected with the cloned cDNA. These MoAbs were further The predicted mature 307-amino acid protein was composed used to show that CD84 is expressed as a single chain cellof two extracellular Ig-like domains, a hydrophobic trans- surface glycoprotein of Mr 64,000 to 82,000, which was membrane region, and an 83-amino acid cytoplasmic do- highly glycosylated. CD84 had a unique pattern of expresmain. The extracellular Ig-like domains presented structural sion, being found predominantly on lymphocytes and monoand sequence homology with a group of members of the Ig cytes. Thus, the glycoprotein HLy9-b is recognized by MoAbs superfamily that included CD2, CD48, CD58, and Ly9. North- previously clustered as CD84 and represents a newly identiern blot analysis showed that the expression of HLy9-b was fied member of the Ig superfamily that may play a significant predominantly restricted to hematopoietic tissues. Chromo- role in leukocyte activation. 2015-04-10T11:10:55Z 2015-04-10T11:10:55Z 1997 info:eu-repo/semantics/article Blood,1997, Vol 90, No 6, pp 2398-2405 0006-4971 http://uvadoc.uva.es/handle/10324/10379 2398 6 2405 Blood 90 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International American Society of Hematology SI