2026-04-14T18:14:04Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/154142024-12-18T08:40:55Zcom_10324_1133com_10324_931com_10324_894col_10324_1209

Bustamante Munguira, Juan Tamayo Gómez, Eduardo Flórez, Santiago Tellería Orriols, Juan José Bustamante Munguira, Elena López Díaz, Javier San Román Calvar, José Alberto Álvarez González, Francisco Javier 2016-01-19T09:21:12Z 2016-01-19T09:21:12Z 2011 Revista Española de Cardiología, 2011;64(11):1056–1059 1885-5857 http://uvadoc.uva.es/handle/10324/15414 10.1016/j.rec.2011.02.027 1056 11 1059 Revista Española de Cardiología 64 The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotide polymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4 (D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis. The control group (n=66) consisted of healthy volunteers. All the polymorphisms were genotyped by means of restriction analysis after their amplification. An association between endocarditis and variants of TLR2 R753Q (P < .001) was observed, but no association with other polymorphisms was found. The TLR2 R753Q co-dominant (odds ratio=13.33), recessive (odds ratio=9.12) and dominant (odds ratio=3.65) genotypes showed a positive association with the infective endocarditis phenotype. The polymorphism TLR2 R753Q was associated with a greater susceptibility towards the development of infective endocarditis. Further studies are required to validate these results and identify other genetic risk factors. eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Endocarditis Toll-Like receptor 2 R753Q polymorphisms are associated with an increased risk of infective endocarditis info:eu-repo/semantics/article