2026-04-27T19:46:04Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/154142024-12-18T08:40:55Zcom_10324_1133com_10324_931com_10324_894col_10324_1209

Toll-Like receptor 2 R753Q polymorphisms are associated with an increased risk of infective endocarditis Bustamante Munguira, Juan Tamayo Gómez, Eduardo Flórez, Santiago Tellería Orriols, Juan José Bustamante Munguira, Elena López Díaz, Javier San Román Calvar, José Alberto Álvarez González, Francisco Javier Endocarditis Producción Científica The ability to respond to the ligands of toll-like receptors (TLR) could be affected by single nucleotide polymorphisms in TLR codifying genes. The influence of the polymorphisms TLR2 (R753Q, R677W), TLR4 (D299G, T399I) and CD14 (C-159T) was consecutively studied in 65 patients with infective endocarditis. The control group (n=66) consisted of healthy volunteers. All the polymorphisms were genotyped by means of restriction analysis after their amplification. An association between endocarditis and variants of TLR2 R753Q (P < .001) was observed, but no association with other polymorphisms was found. The TLR2 R753Q co-dominant (odds ratio=13.33), recessive (odds ratio=9.12) and dominant (odds ratio=3.65) genotypes showed a positive association with the infective endocarditis phenotype. The polymorphism TLR2 R753Q was associated with a greater susceptibility towards the development of infective endocarditis. Further studies are required to validate these results and identify other genetic risk factors. 2016-01-19T09:21:12Z 2016-01-19T09:21:12Z 2011 info:eu-repo/semantics/article Revista Española de Cardiología, 2011;64(11):1056–1059 1885-5857 http://uvadoc.uva.es/handle/10324/15414 10.1016/j.rec.2011.02.027 1056 11 1059 Revista Española de Cardiología 64 eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Elsevier SI