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oai:uvadoc.uva.es:10324/214482021-06-24T07:42:24Zcom_10324_1187com_10324_931com_10324_894com_10324_28542com_10324_952col_10324_1408col_10324_28543

00925njm 22002777a 4500 dc Guevara Pulido, James Oswaldo author Andrés García, José María author Pedrosa Sáez, Rafael author 2014 Enantioenriched trisubstituted lactones were obtained in good yields and moderate to very good enantioselectivities in one-pot process, which implies a sequential organocatalyzed Michael addition of ketones to enals, followed by catalytic intramolecular diastereoselective Tishchenko reaction and lactonization. The final lactones were obtained as single diastereoisomers, demonstrating that the mixture of the anti and syn diastereomers epimerized to the syn hydroxy ester during the oxido-reduction step. Journal of Organic Chemistry, 2014, 79(18), p. 8638-8644 0022-3263 http://uvadoc.uva.es/handle/10324/21448 10.1021/jo5013724 8638 18 8644 Journal of Organic Chemistry 79 Catalizadores Química orgánica One-pot Sequential Organocatalytic Michael-Tishchenko-Lactonization Reactions. Synthesis of Enantioenriched 4, 5, 6 -Trisubstituted - Lactones