2026-04-27T19:56:27Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/215112025-09-17T07:52:03Zcom_10324_1138com_10324_931com_10324_894col_10324_1226

Clinical and Molecular Inflammatory Response in Sjögren Syndrome–Associated Dry Eye Patients Under Desiccating Stress López Miguel, Alberto Teson Yudego, María Luisa Martín Montañez, Vicente Enriquez De Salamanca Aladro, Amalia Stern, Michael E. Calonge, Margarita González García, María Jesús Ojo seco Sjogren, Síndrome de Producción Científica To evaluate the response of the lacrimal function unit in Sjogren syndrome (SS)-associated dry eye patients exposed to 2 simulated daily life environ-mental conditions. Fourteen female SS dry eye patients were exposed for 2 hours to a controlled normal condition (23 C, 45% relative humidity, and air flow 0.10 m/s) and a controlled adverse condition that simulates desic- cating stress (23 C, 5% relative humidity, and air flow 0.10 m/s). The following dry eye tests were performed before and after the exposure: tear osmolarity, phenol red thread test, conjunctival hyperemia, fluorescein tear break-up time, corneal fluorescein staining, conjunctival lissamine green staining, and Schirmer test. Levels of 16 molecules were analyzed in tears by multiplex immu- nobead analysis. 2016-12-09T19:03:59Z 2016-12-09T19:03:59Z 2016 info:eu-repo/semantics/article American Journal of Ophthalmology, 2016, Vol.161, p.133–141 e2 http://uvadoc.uva.es/handle/10324/21511 10.1016/j.ajo.2015.09.039 133 141 American Journal of Ophthalmology eng http://www.sciencedirect.com info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Elsevier Masson SI