2026-05-05T21:06:40Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/216992025-03-26T16:41:31Zcom_10324_1185com_10324_931com_10324_894col_10324_1346

00925njm 22002777a 4500 dc Vila, Mercedes author García, Ana author Girotti ., Alessandra author Alonso Rodrigo, Matilde author Rodríguez Cabello, José Carlos author González Vázquez, Arlyng author Planell i Estany, Josep A. author Engel López, Elisabeth author Buján Varela, Julia author García Honduvilla, Natalio author Vallet Regí, María author 2016 The current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) func- tionalized surfaces. Silicon doped hydroxyapatite (Si-HA), with Ca10(PO4)5.7(SiO4)0.3(OH)1.7h0.3 nominal formula, was surface functionalized with two different types of polymers designed by genetic engineer- ing: ELR-RGD that contain cell attachment specific sequences and ELR-SNA15/RGD with both hydroxya- patite and cells domains that interact with the inorganic phase and with the cells, respectively. These hybrid materials were subjected to in vitro assays in order to clarify if the ELRs coating improved the well-known biocompatible and bone regeneration properties of calcium phosphates materials. The in vitro tests showed that there was a total and homogeneous colonization of the 3D scaffolds by Bone marrow Mesenchymal Stromal Cells (BMSCs). In addition, the BMSCs were viable and able to proliferate and differentiate into osteoblasts. Acta Biomaterialia 2016, Elsevier, vol. 45, p. 349–356 1742-7061 http://uvadoc.uva.es/handle/10324/21699 10.1016/j.actbio.2016.09.016 349 356 45 Biomateriales - Aplicaciones médicas 3D silicon doped hydroxyapatite scaffolds decorated with Elastin-like Recombinamers for bone regenerative medicine