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oai:uvadoc.uva.es:10324/217532021-06-23T11:48:36Zcom_10324_1185com_10324_931com_10324_894col_10324_1346

González de Torre, Israel Weber, Miriam T. Quintanilla Sierra, Luis Alonso Rodrigo, Matilde Jockenhoevel, Stefan Rodríguez Cabello, José Carlos Mela, Petra 2016-12-15T09:25:59Z 2016-12-15T09:25:59Z 2016 Biomaterials Science, 2016 vol. 4, 1361-1370 2047-4830 http://uvadoc.uva.es/handle/10324/21753 10.1039/C6BM00300A 1361 4 1370 Biomaterials Science Producción Científica In the field of tissue engineering, the properties of the scaffolds are of crucial importance for the success of the application. Hybrid materials combine the properties of the different components that constitute them. In this study hybrid gels of Elastin-Like Recombinamer (ELR) and fibrin were prepared with a range of polymer concentrations and ELR-to-fibrin ratios. The correlation between SEM micrographs, porosities, swelling ratios and rheological properties was discussed and a poroelastic mechanism was suggested to explain the mechanical behavior of the hybrid gels. Applicability as scaffold materials for cardiovascular tissue engineering was shown by the realization of cell-laden matrixes which supported the synthesis of collagens as revealed by immunohistochemical analysis. As a proof of concept, a tissue-engineered heart valve was fabricated by injection moulding and cultivated in a bioreactor for 3 weeks under dynamic con- ditions. Tissue analysis revealed the production of collagen I and III, fundamental proteins for cardio- vascular constructs. Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA152A12-2, VA244U13 y VA155A12-2) Ministerio de Industria, Economía y Competitividad (proyectos MAT-2010-15982, MAT2010- 15310, PRI-PIBAR-2011-1403 y MAT2012-38043-C02-01) application/pdf eng Royal Society of Chemistry info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Colágeno Hybrid elastin-like recombinamer-fibrin gels: physical characterization and in vitro evaluation for cardiovascular tissue engineering applications info:eu-repo/semantics/article http://pubs.rsc.org/ info:eu-repo/grantAgreement/EC/H2020/263363 info:eu-repo/grantAgreement/EC/H2020/278557 info:eu-repo/grantAgreement/EC/H2020/317304 SI