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Rodríguez Cabello, José Carlos Arias Vallejo, Francisco Javier Alonso Rodrigo, Matilde Girotti ., Alessandra 2017-07-27T11:00:59Z 2017-07-27T11:00:59Z 2016 Advanced Drug Delivery Reviews Volume 97, 1 February 2016, Pages 85-100 http://uvadoc.uva.es/handle/10324/24759 10.1016/j.addr.2015.12.007 Producción Científica The use of recombinant elastin-like materials, or elastin-like recombinamers (ELRs), in drug-delivery applications is reviewed in this work. Although ELRs were initially used in similar ways to other, more conventional kinds of polymeric carriers, their unique properties soon gave rise to systems of unparalleled functionality and efficiency, with the stimuli responsiveness of ELRs and their ability to self-assemble readily allowing the creation of advanced systems. However, their recombinant nature is likely the most important factor that has driven the current breakthrough properties of ELR-based delivery systems. Recombinant technology allows an unprecedented degree of complexity in macromolecular design and synthesis. In addition, recombinant materials easily incorporate any functional domain present in natural proteins. Therefore, ELR-based delivery systems can exhibit complex interactions with both their drug load and the tissues and cells towards which this load is directed. Selected examples, ranging from highly functional nanocarriers to macrodepots, will be presented. Ministerio de Economía, Industria y Competitividad (Project PRI-PIBAR-2011-1403, MAT2012-38043, MAT2013-42473-R and MAT2013- 4 17 23-R) Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. (VA152A12, VA155A12 and VA313U14) application/pdf eng Elsevier info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Elastin-like polypeptides in drug delivery info:eu-repo/semantics/article http://www.sciencedirect.com/science/article/pii/S0169409X15300016 info:eu-repo/grantAgreement/EC/H2020/642687 SI