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2017-08-31T10:05:19Z urn:hdl:10324/25327 Carbon Monoxide inhibits hypoxic pulmonary vasoconstriction in rats by a cGMP-independent mechanism Tamayo Lomas, Luis Mariano López López, José Ramón Castañeda, Javier Monóxido de carbono Hypoxia Producción Científica Hypoxia activates erythropoietin-producing cells, chemoreceptor cells of the carotid body and pul- monary artery smooth muscle cells (PSMC) with a com- Key words Hypoxia · Pulmonary artery · Carbon monoxide&bdy: parable arterial PO2 threshold of some 70 mmHg. The inhibition by CO of the hypoxic responses in the two for- mer cell types has led to the proposal that a haemopro- tein is involved in the detection of the PO2 levels. Here, we report the effect of CO on the hypoxic pulmonary va- soconstriction (HPV). Pulmonary arterial pressure (PAP) was measured in an in situ, blood-perfused lung prepara- tion. PAP in normoxia (20% O2, 5% CO2) . 2017-08-31T10:05:19Z 2017-08-31T10:05:19Z 1997 info:eu-repo/semantics/article Pflügers Arch - Eur J. Physiol (1997) 0031-6768 http://uvadoc.uva.es/handle/10324/25327 698 704 Pflügers Arch - Eur J. Physiol 434 eng info:eu-repo/semantics/openAccess Springer Verlag