2026-04-27T21:30:42Zhttps://uvadoc.uva.es/oai/requestoai:uvadoc.uva.es:10324/253272021-10-18T12:37:59Zcom_10324_32522com_10324_952com_10324_894com_10324_43677com_10324_954com_10324_1134com_10324_931col_10324_32523col_10324_43678col_10324_1213
Carbon Monoxide inhibits hypoxic pulmonary vasoconstriction in rats by a cGMP-independent mechanism
Tamayo Lomas, Luis Mariano
López López, José Ramón
Castañeda, Javier
Monóxido de carbono
Hypoxia
Producción Científica
Hypoxia activates erythropoietin-producing cells, chemoreceptor cells of the carotid body and pul- monary artery smooth muscle cells (PSMC) with a com-
Key words Hypoxia · Pulmonary artery · Carbon monoxide&bdy:
parable arterial PO2 threshold of some 70 mmHg. The
inhibition by CO of the hypoxic responses in the two for- mer cell types has led to the proposal that a haemopro- tein is involved in the detection of the PO2 levels. Here, we report the effect of CO on the hypoxic pulmonary va- soconstriction (HPV). Pulmonary arterial pressure (PAP)
was measured in an in situ, blood-perfused lung prepara- tion. PAP in normoxia (20% O2, 5% CO2) .
2017-08-31
2017-08-31
1997
info:eu-repo/semantics/article
Pflügers Arch - Eur J. Physiol (1997)
0031-6768
http://uvadoc.uva.es/handle/10324/25327
698
704
Pflügers Arch - Eur J. Physiol
434
eng
info:eu-repo/semantics/openAccess
Springer Verlag