2026-05-05T20:28:51Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/261382021-10-21T14:27:29Zcom_10324_31661com_10324_952com_10324_894com_10324_23040com_10324_954col_10324_31662col_10324_23041

Lopes, Joana Mustapa, Ana Najwa Binti Pantic, Milica Bermejo Roda, Maria Dolores Martín Martínez, Ángel Novak, Zoran Knez, Zeljko Cocero Alonso, María José Materiales Producción Científica The use of natural polysaccharides is especially attractive to the pharmaceutical industry because of their stability, availability, renewability and low toxicity. In this study, cellulose aerogels obtained from cellulose/ionic liquid solutions were prepared by supercritical drying with surface areas ranged from 154 to 434 m2 g−1, pore volume from 0.3 to 2.4 cm3 g−1 and pore diameter from 7.9 to 34 nm. Drug loading capacity was investigated by impregnating phytol as model compound into the aerogels, using supercritical CO2 at 100 bar, 40 °C and mass ratio of phytol per gram of aerogel 10:1. The quantity of drug present is consistent in each aerogel. The aerogel prepared from 2 wt% cellulose in [Emim][DEP] solution showed the highest loading capacity. The high amount of drug loaded (approx 50% w/w) in the cellulose aerogels prepared from ionic liquid solutions shows their potential uses in the pharmaceutical or medical industry. 2017-10-05 2017 info:eu-repo/semantics/article The Journal of Supercritical Fluids, Diciembre 2017, vol 130, p. 17-22 0896-8446 http://uvadoc.uva.es/handle/10324/26138 10.1016/j.supflu.2017.07.018 17 22 The Journal of Supercritical Fluids 130 eng https://doi.org/10.1016/j.supflu.2017.07.018 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Elsevier B.V. Attribution-NonCommercial-NoDerivatives 4.0 International Elsevier B.V.