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Infante Blanco, Rebeca Martín Álvarez, José Miguel Andrés Juan, Celia Nieto Román, Francisco Javier 2018-03-12T12:08:35Z 2018-07-07T23:40:44Z 2017 Organic Letters, 2017, 19 (7), pp 1516–1519 1523-7060 http://uvadoc.uva.es/handle/10324/28951 10.1021/acs.orglett.7b00252 Producción Científica An efficient enantioselective Me2Zn-mediated mono addition of phenylacetylene to α-diketones in the presence of a chiral perhydro-1,3-benzoxazine ligand is described. At temperatures higher than -20 ºC a kinetic resolution of the resulting α-hydroxy ketone occurs which greatly improves the enantioselectivity although with moderate chemical yield. The alkynylation of nonsymmetrical aromatic diketones with electronically different substituents on the aromatic rings proceed with high regioselectivity. This procedure allows the preparation of α-hydroxy-α-ynyl-ketones as highly enantioenriched materials. 2018-07-07 Ministerio de Economía, Industria y Competitividad (Project CTQ2014-59870 P) Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA064U13) application/pdf eng American Chemical Society info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Dimethylzinc-mediated addition of phenylacetylene to α-diketones catalyzed by chiral perhydro-1,3-benzoxazines info:eu-repo/semantics/article https://pubs.acs.org/doi/abs/10.1021/acs.orglett.7b00252 SI