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2018-03-19T12:23:42Z urn:hdl:10324/29152 Metallamacrocycle formation through dimerization of metal bioconjugates derived from amino acids and peptides Álvarez González, Celedonio Manuel García Rodríguez, Raúl Miguel San José, Daniel Producción Científica Metallamacrocycles of 12, 16, and 22 members are obtained by deprotonation of the carboxylic group of the side chain of iminopyridine complexes derived from the amino acid β-alanine, and the peptides Gly–Gly and Gly–Gly–Gly. Instead of the expected intramolecular attack to give tridentate (N,N,O) ligands, the deprotonated carboxylate attacks in an inter-molecular manner to give dimers in which the ligand acts as a bridge bonded in a κ2(N,N′) chelating fashion to one metal and as κ(O) to the other metal. The formation of the dimers is supported by NMR spectroscopy, mass spectrometry and X-ray crystallography. 2018-03-19T12:23:42Z 2018-03-19T12:23:42Z 2016 info:eu-repo/semantics/article Dalton Transactions 2016, 45 , pp. 963 – 972 1477-9226 http://uvadoc.uva.es/handle/10324/29152 10.1039/C5DT01256B eng http://pubs.rsc.org/en/content/articlelanding/2016/dt/c5dt01256b#!divAbstract info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Royal Society of Chemistry