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00925njm 22002777a 4500 dc Cantera Ruiz De Pellon, Sara author Muñoz Torre, Raúl author Lebrero Fernández, Raquel author López Alonso, Juan Carlos author Rodríguez Muñoz, Yadira author García Encina, Pedro Antonio author 2018 Methane, with a global warming potential twenty five times higher than that of CO2 is the second most important greenhouse gas emitted nowadays. Its bioconversion into microbial molecules with a high retail value in the industry offers a potential cost-efficient and environmentally friendly solution for mitigating anthropogenic diluted CH4-laden streams. Methane bio-refinery for the production of different compounds such as ectoine, feed proteins, biofuels, bioplastics and polysaccharides, apart from new bioproducts characteristic of methanotrophic bacteria, has been recently tested in discontinuous and continuous bioreactors with promising results. This review constitutes a critical discussion about the state-of-the-art of the potential and research niches of biotechnologies applied in a CH4 biorefinery approach. Current Opinion in Biotechnology, Volume 50, 2018, Pages 128-135 0958-1669 http://uvadoc.uva.es/handle/10324/30102 10.1016/j.copbio.2017.12.021 Technologies for the bioconversion of methane into more valuable products