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oai:uvadoc.uva.es:10324/307702025-02-18T13:38:45Zcom_10324_1186com_10324_931com_10324_894col_10324_1404

Rodríguez Méndez, María Luz Alessio, Priscila Saja Saez, José Antonio De H.B. Aoki, Pedro 2018-07-17T09:44:45Z 2011 RSC Advances vol. 1 p. 211-218 2046-2069 http://uvadoc.uva.es/handle/10324/30770 10.1039/C1RA00141H Producción Científica The surface-enhanced resonance Raman scattering (SERRS) technique and an electronic tongue system based on cyclic voltammetry were coupled combining structural information and sensitivity. Layer-by-Layer (LbL) films containing the phospholipids cardiolipin (CLP) and dipalmitoyl phosphatidyl glycerol (DPPG) were deposited onto ITO to obtain functional electrodes forming an array of sensing units. The phospholipids were applied here as biological membrane mimetic systems, taking advantage of their affinity with pharmaceutical drugs. The electronic tongue was used in the detection of methylene blue (MB) at micromolar concentrations. SERRS spectra were also collected directly from the sensing units (in situSERRS), which was possible due to the adsorption of Ag nanoparticles (AgNPs) within the phospholipid LbL films. This approach also induced an enhancement of the voltammetric signal of the sensing units, especially in the case of CLP. Complementary, the LbL films were morphologically characterized using micro-Raman and scanning electron microscopy-field emission gun (SEM-FEG). 2022-07-6 2022-07-06 application/pdf eng info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Attribution-NonCommercial-NoDerivatives 4.0 International Combining SERRS and electrochemistry to characterize sensors based on biomembrane mimetic models formed by phospholipids info:eu-repo/semantics/article SI