2026-04-23T20:32:46Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/313522021-06-24T07:24:31Zcom_10324_23459com_10324_954com_10324_894col_10324_23462

Bispectral Analysis of Spontaneous EEG Activity from Patients with Moderate Dementia Due to Alzheimer’s Disease Gómez Peña, Carlos Vaquerizo Villar, Fernando Poza Crespo, Jesús Ruiz Gómez, Saúl José Tola Arribas, Miguel Ángel Cano, Mónica Hornero Sánchez, Roberto Producción Científica Dementia due to Alzheimer’s disease (AD) is a common disorder with a great impact on the patients’ quality of life. The aim of this pilot study was to characterize spontaneous electroencephalography (EEG) activity in dementia due to AD using bispectral analysis. Five minutes of EEG activity were recorded from 17 patients with moderate dementia due to AD and 19 age-matched controls. Bispectrum results revealed that AD patients are characterized by an increase of phase coupling at low frequencies in comparison with controls. Additionally, some bispectral features calculated from the bispectrum showed significant differences between both groups (p < 0.05, Mann-Whitney U test with Bonferroni’s correction). Finally, a stepwise logistic regression analysis with a leave-one-out cross-validation procedure was used for classification purposes. An accuracy of 86.11% (sensitivity = 88.24%; specificity =84.21%) was achieved. This study suggests the usefulness of bispectral analysis to provide further insights into the underlying brain dynamics associated with AD 2018-09-03T10:45:53Z 2018-09-03T10:45:53Z 2017 info:eu-repo/semantics/conferenceObject 978-1-5090-2809-2 http://uvadoc.uva.es/handle/10324/31352 eng info:eu-repo/semantics/restrictedAccess