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<dc:creator>Crespo Senado, Andrea</dc:creator>
<dc:creator>Vaquerizo Villar, Fernando</dc:creator>
<dc:creator>Álvarez González, Daniel</dc:creator>
<dc:creator>Gutierrez Tobal, Gonzalo César</dc:creator>
<dc:creator>Barroso García, Verónica</dc:creator>
<dc:creator>Cerezo Hernández, Ana</dc:creator>
<dc:creator>López Muñiz, Graciela</dc:creator>
<dc:creator>Kheirandish Gozal, Leila</dc:creator>
<dc:creator>Gozal, David</dc:creator>
<dc:creator>Hornero Sánchez, Roberto</dc:creator>
<dc:creator>Campo Matias, Félix del</dc:creator>
<dc:date>2017</dc:date>
<dc:description>Producción Científica</dc:description>
<dc:description>Background. Standard pediatric in-lab polysomnography (PSG) is&#xd;
relatively unavailable and particularly intrusive for children. In low resource&#xd;
settings, nocturnal oximetry has been proposed as a feasible and&#xd;
potentially reliable screening tool for childhood obstructive sleep apneahypopnea&#xd;
syndrome (OSAHS), although additional confirmatory evidence is&#xd;
needed.&#xd;
Aims and objectives. Discrete wavelet transform (DWT) could be a useful&#xd;
tool to characterize fluctuations in nocturnal oximetry. We aimed at&#xd;
designing and assessing a model for detecting childhood OSAHS using&#xd;
anthropometric and DWT features.&#xd;
Methods. A total of 298 children with clinical suspicion of OSAHS&#xd;
underwent in-lab PSG. A cut-off of 5 events/h was stipulated as confirming&#xd;
OSAHS. DWT was used to inspect the spectral content of oximetry in&#xd;
frequency bands linked with apnea pseudo-periodicity: detail levels D9&#xd;
(0.024-0.049 Hz) and D10 (0.012-0.024 Hz). Mean, variance, minimum, and maximum of DWT coefficients were computed. Stepwise logistic regression&#xd;
was employed to build an OSAHS model from DWT, age, gender, and body&#xd;
mass index (BMI) z score. Training (60%) and test (40%) sets were&#xd;
randomly allocated.&#xd;
Results. Age, gender, D9 mean, and D10 variance were automatically&#xd;
selected. Our model reached 79.1% sensitivity, 81.7% specificity, 4.33 LR+,&#xd;
0.26 LR-, and 80.5% accuracy in the test set.&#xd;
Conclusions. Features from DWT coefficients and anthropometric&#xd;
variables such as age provide complementary information that enables&#xd;
detection of moderate-to-severe childhood OSAHS in a high pre-test&#xd;
probability cohort.</dc:description>
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<dc:identifier>http://uvadoc.uva.es/handle/10324/31357</dc:identifier>
<dc:language>eng</dc:language>
<dc:title>Automated detection of childhood sleep apnea using discrete wavelet transform of nocturnal oximetry and anthropometric variables</dc:title>
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