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Neves García, Tomaz Vélez Blasco, Andrea Martínez de Ilarduya Martínez de Ilarduya, Jesús María Espinet Rubio, Pablo 2018-11-14T08:09:16Z 2018-11-14T08:09:16Z 2018 Chemical Communications, 2018,54, 11809-11812 1359-7345 http://uvadoc.uva.es/handle/10324/32631 10.1039/C8CC06358C Producción Científica Chiral-diamine catalyzed addition of ZnMe2 to PhC(O)CF2X (in dichloromethane at −30 °C) affords fluorinated alkyl tertiary alcohols in high yield (quantitative for X = H, F, Cl; 84% for X = CF3) and up to 99% ee. These conditions are similarly very efficient for other various ArC(O)CF3 molecules. A fine analysis of the results can be performed based on a double-cycle mechanism. Ministerio de Economía, Industria y Competitividad (Projects CTQ-2016-80913-P and CTQ2014-52796) Junta de Castilla y León (programa de apoyo a proyectos de investigación - Ref. VA051P17) application/pdf eng Royal Society of Chemistry info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ © 2018 Royal Society of Chemistry Attribution-NonCommercial-NoDerivatives 4.0 International Química organometálica Organometallic chemistry Highly enantioselective addition of dimethylzinc to fluorinated alkyl ketones, and the mechanism behind it info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion https://pubs.rsc.org/en/content/articlelanding/2018/cc/c8cc06358c#!divAbstract SI