2026-05-05T20:56:16Zhttps://uvadoc.uva.es/oai/request

oai:uvadoc.uva.es:10324/335062025-03-26T19:10:04Zcom_10324_22821com_10324_954com_10324_894col_10324_22822

Fernández Colino, Alicia Quinteros, Daniela A. Girotti ., Alessandra Palma, Santiago D. Arias Vallejo, Francisco Javier 2018-12-18T08:04:12Z 2018-12-18T08:04:12Z 2017 Molecular Pharmaceutics, 2017, 14 (12), pp 4498–4508 1543-8384 http://uvadoc.uva.es/handle/10324/33506 10.1021/acs.molpharmaceut.7b00615 Producción Científica This work focuses on improving the effectiveness of current therapies against glaucoma by incorporating self-assembled polymers into the ophthalmic formulation. To that end, we first studied the influence of the dispersing medium on the mechanical performance of self-assembling elastin-like (EL) and silk-elastin-like (SEL) hydrogels by conducting rheological tests. These polymers were subsequently incorporated into the antiglaucoma formulation, which contains timolol maleate (TM) as active ingredient, and in vivo tests, namely adhesion tests and intraocular pressure measurements (IOP), were performed in New Zealand rabbits. An enhanced reduction in IOP due to the presence of the polymers was observed. Moreover, differences in the effectiveness between both EL- and SEL-hydrogels, which can be explained on the basis of the different rheological properties displayed by these two systems, were also encountered. The results point to the potential of this system as a basis for the development of an ophthalmic formulation against glaucoma. European Social Fund (ESF) and European Regional Development Fund (ERDF) Comisión Europea (proyectos NMP-2014-646075, HEALTH-F4-2011-278557, PITN-GA-2012-317306, y MSCA-ITN-2014-642687) Ministerio de Economía, Industria y Competitividad (Projects MAT2015-68901-R, MAT2016-79435-R and MAT2016-78903-R) Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA244U13 y VA313U14) CIBER-BBN, Instituto de Salud Carlos III a través de la "Red de Medicina Regenerativa y Terapia Celular de Castilla y León", con el apoyo del “Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) y la Universidad Nacional de Córdoba (Argentina) application/pdf eng American Chemical Society info:eu-repo/semantics/openAccess © 2017 American Chemical Society Glaucoma Elastina Elastin Self-asembling elastin-like hydrogels for timolol delivery: development of an ophthalmic formulation against glaucoma info:eu-repo/semantics/article https://pubs.acs.org/doi/abs/10.1021/acs.molpharmaceut.7b00615 SI